Tumour Necrosis Factor-Î‘, Interleukin-1 and Interleukin-6 Serum Levels and Its Correlation with Pain Severity in Chronic Tension-Type Headache Patients: Analysing Effect of Dexketoprofen Administration
Keywords:chronic tension-type headache, Dexketoprofen, IL-1, IL-6, TNF-Î±
AIM: The purpose of this study is to see the effect of Dexketoprofen on TNF-Î±, IL-1, and IL-6 serum levels in Chronic Tension-Type Headache (CTTH) patients and its correlation with pain severity.
METHOD: The study subjects were recruited consecutively from the study population. Venous blood was taken at baseline to measure serum levels of TNF-Î±, IL-1, and IL-6 and after ten consecutive days of Dexketoprofen 25 mg once daily.
RESULTS: Twenty three subjects participated in this study, 3 male (13.0%) and 20 female (87%). A significant difference between NRS score at baseline and after treatment (4.86 Â± 1.82 vs. 1.96 Â± 1.40, p = 0.001) was found. No significant difference found between baseline and after treatment TNF-Î± (1.48 Â± 0.65 pg/dl vs. 1.48 Â± 0.63 pg/dl, p = 0.963), IL-1 (0.16 Â± 0.80 pg/dl vs. 0.26 Â± 0.31 pg/dl, p = 0.168) nor IL-6 serum levels (1.06 Â± 0.83 pg/dl vs. 1.04 Â± 0.81 pg/dl, p = 0.915). A weak negative (R = -0.266) non significant correlation (p = 0.219) was found between NRS score and TNF-Î±. A positive weak negative (R = 0.221) non significant correlation (p = 0.311) between NRS score and IL-1. NRS score and IL-6 had a negative very weak (R = -0.019) non significant negative correlation (p = 0.931).
CONCLUSIONS: Dexketoprofen decreased pain intensity significantly (p = 0.001), but had no effect on TNF-Î± IL-1 nor IL-6 serum levels. NRS score had a weak and non significant negative correlation with TNF-Î±, a weak and non significant positive correlation with IL-1, and a very weak and non significant negative correlation with IL-6 serum levels.
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