Correlation between Lymphocyte CD4 Count, Treatment Duration, Opportunistic Infection and Cognitive Function in Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) Patients

Authors

  • Fasihah Irfani Fitri Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara
  • Aldy Safruddin Rambe Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara
  • Aida Fitri Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara

DOI:

https://doi.org/10.3889/oamjms.2018.152

Keywords:

CD4, HIV – AIDS, Cognitive function

Abstract

BACKGROUND: Human immunodeficiency virus (HIV) infection is an epidemic worldwide, despite the marked benefits of antiretroviral therapy (ARV) in reducing severe HIV-associated dementia. A milder form of neurocognitive disorders are still prevalent and remain a challenge.

AIM: This study aimed to determine the correlation between plasma cluster of differentiation 4 (CD4) lymphocyte, duration of ARV treatment, opportunistic infections, and cognitive function in HIV-AIDS patients.

METHODS: A cross-sectional study involving 85 HIV-AIDS patients was conducted at Adam Malik General Hospital Medan, Indonesia. All subjects were subjected to physical, neurologic examination and Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) to assess cognitive function and measurement of lymphocyte CD4 counts.

RESULTS: Out of the 85 subjects evaluated, the proportion concerning sexes include 52 males (61.2 %) and 33 females (38.8%). The mean age was 38.53 ± 9.77 years old. There was a significant correlation between CD4 lymphocyte counts and MoCA-INA score (r = 0.271, p = 0.012), but there was no significant correlation between duration of ARV treatment and MoCA-INA score. There was also no difference in MoCA-INA score based on the presence of opportunistic infection.

CONCLUSION: Lymphocyte CD4 count was independently correlated with cognitive function in HIV-AIDS patients.

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References

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Published

2018-04-13

How to Cite

1.
Fitri FI, Rambe AS, Fitri A. Correlation between Lymphocyte CD4 Count, Treatment Duration, Opportunistic Infection and Cognitive Function in Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) Patients. Open Access Maced J Med Sci [Internet]. 2018 Apr. 13 [cited 2024 May 26];6(4):643-7. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.152

Issue

Section

B - Clinical Sciences

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