Multiple Primary Acral Lentiginous Melanomas (MPALM)


  • Miriam González Department of Internal Medicine, Autonomous University of Honduras (UNAH), Service of Dermatology and Dermatologic Surgery, School University Hospital (HEU), Tegucigalpa 11101
  • Georgi Tchernev Medical Institute of Ministry of Interior (MVR) Sofia, Department of Dermatology and Dermatologic Surgery, Sofia; ”Onkoderma”- Policlinic for Dermatology and Dermatologic Surgery, Sofia
  • Anastasiya Atanasova–Chokoeva ”Onkoderma”- Policlinic for Dermatology and Dermatologic Surgery, Sofia
  • Katlein França Institute for Bioethics & Health Policy; Department of Dermatology & Cutaneous Surgery; Department of Psychiatry & Behavioral Sciences, University of Miami, Miller School of Medicine - Miami, FL
  • Torello Lotti University of Rome “ G.Marconi”, Rome



melanoma, multiple primary tumours, acral located tumours, amputations, staging


We present a rare case of a patient with multiple primary acral lentiginous melanomas of the foot. We would like to highlight the importance of whole-skin examination in all patients, even by the general practitioners, aiming the maximal early detection of acral lentiginous melanomas, considering their rapid progression, early metastatic spread and extremely poor prognosis. It can be extrapolated from current literature; however, that appropriate management of these patients, including staging work and surgical intervention, is to be determined by the individual characteristics of the melanoma and the patient's concomitant risk factors, if any.


Download data is not yet available.


Metrics Loading ...

Plum Analytics Artifact Widget Block


Asgari MM, Shen L, Sokil MM, Yeh I, Jorgenson E. Prognostics factors and survival in acral lentiginous melanoma. Br J Dermatol. 2017 Apr 22.

Kuchelmeister C, Schaumburg-Lever G, Garbe C. Acral cutaneous melanoma in Caucasians: clinical features, histopathology and prognosis in 112 patients. Br J Dermatol. 2000; 143(2):275-80. PMid:10951133

Bradford PT, Goldstein AM, McMaster ML, Tucker MA. Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. Arch Dermatol. 2009; 145(4):427-34. PMid:19380664 PMCid:PMC2735055

Nam KW, Bae YC, Nam SB, Kim JH, Kim HS, Choi YJ.Characteristics and Treatment of Cutaneous Melanoma of the Foot. Arch Plast Surg. 2016; 43(1):59-65. PMid:26848447 PMCid:PMC4738130

Hayes AJ, Clark MA, Harries M, Thomas JM. Management of in-transit metastases from cutaneous malignant melanoma. Br J Surg. 2004; 91(6):673-82. PMid:15164434

Lacruz G, Cárdenas I, Carrera C, Díaz A, Puig-Butillè JA, Badenas C, Malvehy J, Puig S. Multiple primary acral melanomas in two young caucasian patients. Dermatology. 2014;228(4):307-10. PMid:24942556

Hutcheson AC, McGowan JW 4th, Maize JC Jr, Cook J. Multiple primary acral melanomas in African-Americans: a case series and review of the literature. Dermatol Surg. 2007;33(1):1-10.



How to Cite

González M, Tchernev G, Atanasova–Chokoeva A, França K, Lotti T. Multiple Primary Acral Lentiginous Melanomas (MPALM). Open Access Maced J Med Sci [Internet]. 2017 Oct. 2 [cited 2023 Mar. 21];5(6):805-6. Available from:



Clinical Image

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>