Pathological Profile, Early Complications, Functional and Oncological Outcome after Radical Cystectomy - Ileal Conduit for Bladder Cancer Patients in Sanglah General Hospital between January 2013 and December 2016

Authors

  • Yudiana Wayan Department of Surgery, Medical Faculty, Udayana University-Sanglah General Hospital, Bali
  • Pratiwi Dinar Ayu Department of Surgery, Medical Faculty, Udayana University-Sanglah General Hospital, Bali
  • Oka A. A. Gde Department of Surgery, Medical Faculty, Udayana University-Sanglah General Hospital, Bali
  • Niryana Wayan Department of Surgery, Medical Faculty, Udayana University-Sanglah General Hospital, Bali
  • I Putu Eka Widyadharma Department of Neurology, Medical Faculty, Udayana University-Sanglah General Hospital, Bali

DOI:

https://doi.org/10.3889/oamjms.2018.384

Keywords:

Bladder cancer, radical cystectomy, ileal conduit, the oncological outcome

Abstract

BACKGROUND: Radical cystectomy is the standard treatment for nonmetastatic bladder cancer (muscle-invasive and selective superficial bladder cancer). There are many types of urinary diversion after this procedure; the ileal conduit is the most and simplest one.

AIM: To asses clinical, pathological profile, early complication, functional and oncological outcome after radical cystectomy and ileal conduit for muscle-invasive bladder cancer patients.

METHOD: Between January 2013 and December 2016, there were 68 patients diagnosed with bladder cancer. From those patients, 24 (35.29%) patients had been performed radical cystectomy with ileal conduit type for urinary diversion (100%). Patients demographic, clinical and pathological profile, early postoperative complication, functional and oncological outcome were collected from the medical record.

RESULT: Among the 24 patients who underwent radical cystectomy, 20 patients were male (83.3%) with the mean age was 57.3 y.o (33–77 y.o). Twelve patients (50%) showed pT4 and pT2 respectively. Based on pathological result 20 patient (83.34%) had the urothelial carcinoma, three patients (12.5%) had squamous cell carcinoma, and one patient (4.1%) had adenocarcinoma. Two patients (8.3%) got neoadjuvant chemotherapy, and nine patient (37.5%) of patients followed adjuvant chemotherapy after surgery. Wound dehiscence, fistula enterocutan, prolong ileus, leakage anastomosis and sepsis were kind of complication after surgery. One year's survival rate is 84%, mortality rate 20.8% and a recurrence rate of 20.8% in 4 years follow up.

CONCLUSION: Radical cystectomy and ileal conduit type of urinary diversion still become the preferable procedure for nonmetastatic bladder cancer with good functional and oncological outcome.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Huang Y, Pan X, Zhou Q, Huang H, Li L, Cui X, Wang G, Jizhong R, Yin L, Xu D, Hong Y. Quality-of-life outcomes and unmet needs between ileal conduit and orthotopic ileal neobladder after radical cystectomy in a Chinese population: a 2-to-1 matched-pair analysis. BMC urology. 2015; 15(1):117. https://doi.org/10.1186/s12894-015-0113-7 PMid:26610351 PMCid:PMC4662020

Shelbaia A, Salem HK, Emran A, Raouf MA, Rahman SA. Long term complications after radical cystoprostatectomy with orthotopic diversion in male patients: Preliminary experience. African Journal of Urology. 2013; 19(2). https://doi.org/10.1016/j.afju.2013.02.008

J. Joy Lee, Dipen J. Parekh, and Mark L. Gonzalgo, Open Radical Cystectomy. B.R. Konety and S.S. Chang (eds.), Management of Bladder Cancer: 293A Comprehensive Text With Clinical Scenarios, Springer Science+Business Media New York, 2015.

Kakehi Y, Hirao Y, Kim WJ, Ozono S, Masumori N, Miyanaga N, Nasu Y, Yokomizo A. Bladder cancer working group report. Japanese journal of clinical oncology. 2010; 40(Suppl 1):i57-64. https://doi.org/10.1093/jjco/hyq128 PMid:20870921

Colombo R, Naspro R. Ileal conduit as the standard for urinary diversion after radical cystectomy for bladder cancer. European Urology Supplements. 2010; 9(10):736-44. https://doi.org/10.1016/j.eursup.2010.09.001

Hautmann RE, Hautmann SH, Hautmann O. Complications associated with urinary diversion. Nature Reviews Urology. 2011; 8(12):667. https://doi.org/10.1038/nrurol.2011.147 PMid:22045349

Meyer JP, Blick C, Arumainayagam N, Hurley K, Gillatt D, Persad R, Fawcett D. A threeâ€centre experience of orthotopic neobladder reconstruction after radical cystectomy: revisiting the initial experience, and results in 104 patients. BJU international. 2009; 103(5):680-3. https://doi.org/10.1111/j.1464-410X.2008.08204.x PMid:19076133

Cookson MS, Chang SS, Wells N, Parekh DJ, SMITH JR JA. Complications of radical cystectomy for nonmuscle invasive disease: comparison with muscle invasive disease. The Journal of urology. 2003; 169(1):101-4. https://doi.org/10.1016/S0022-5347(05)64045-1

Colombo R. Editorial comment on: defining early morbidity of radical cystectomy for patients with bladder cancer using a standardized reporting methodology. European urology. 2009; 55(1):175-6. https://doi.org/10.1016/j.eururo.2008.07.033 PMid:18675503

Maffezzini M, Campodonico F, Canepa G, Gerbi G, Parodi D. Current perioperative management of radical cystectomy with intestinal urinary reconstruction for muscle-invasive bladder cancer and reduction of the incidence of postoperative ileus. Surgical Oncology. 2008; 17(1):41-8. https://doi.org/10.1016/j.suronc.2007.09.003 PMid:17962014

Pycha A, Comploj E, Martini T, Trenti E, Mian C, Lusuardi L, Lodde M, Mian M, Palermo S. Comparison of complications in three incontinent urinary diversions. European urology. 2008; 54(4):825-34. https://doi.org/10.1016/j.eururo.2008.04.068 PMid:18502026

Meller AE, Nesrallah LJ, Dall'Oglio MF, Srougi M. Complications in radical cystectomy performed at a teaching hospital. Int Braz J Urol. 2002; 28:522–5. PMid:15748400

Shabsigh A, Korets R, Vora KC, Brooks CM, Cronin AM, Savage C, Raj G, Bochner BH, Dalbagni G, Herr HW, Donat SM. Defining early morbidity of radical cystectomy for patients with bladder cancer using a standardized reporting methodology. European urology. 2009; 55(1):164-76. https://doi.org/10.1016/j.eururo.2008.07.031 PMid:18675501

Hollenbeck BK, Miller DC, Taub D, Dunn RL, Khuri SF, Henderson WG, Montie JE, UNDERWOOD III WI, Wei JT. Identifying risk factors for potentially avoidable complications following radical cystectomy. The Journal of urology. 2005; 174(4):1231-7. https://doi.org/10.1097/01.ju.0000173923.35338.99 PMid:16145376

Abol-Enein HA, Abdul-Muhsin AS, Alhallaq YM. Ileal-conduit following cystectomy, single-institution revision of indications and outcome. Saudi medical journal. 2008; 29(1):65-8. PMid:18176675

Boström PJ, Kössi J, Laato M, Nurmi M. Risk factors for mortality and morbidity related to radical cystectomy. BJU international. 2009; 103(2):191-6. https://doi.org/10.1111/j.1464-410X.2008.07889.x PMid:18671789

Berrum-Svennung I, Hedelin H, Holmang S. Costs of radical cystectomy. Scand J Urol Nephrol. 2005; 39:36–41. https://doi.org/10.1080/00365590410002537 PMid:15764269

Kim SH, Yu A, Jung JH, Lee YJ, Lee ES. Incidence and risk factors of 30-day early and 90-day late morbidity and mortality of radical cystectomy during a 13-year follow-up: a comparative propensity-score matched analysis of complications between neobladder and ileal conduit. Japanese journal of clinical oncology. 2014; 44(7):677-85. https://doi.org/10.1093/jjco/hyu051 PMid:24791782

Mattei A, Birkhaeuser FD, Baermann C, Warncke SH, Studer UE. To stent or not to stent perioperatively the ureteroileal anastomosis of ileal orthotopic bladder substitutes and ileal conduits? Results of a prospective randomized trial. The Journal of urology. 2008; 179(2):582-6. https://doi.org/10.1016/j.juro.2007.09.066 PMid:18078958

Chahal R, Sundaram SK, Iddenden R, Forman DF, Weston PM, Harrison SC. A study of the morbidity, mortality and long-term survival following radical cystectomy and radical radiotherapy in the treatment of invasive bladder cancer in Yorkshire. European urology. 2003; 43(3):246-57. https://doi.org/10.1016/S0302-2838(02)00581-X

Huang J, Lin T, Liu H, Xu K, Zhang C, Jiang C, Huang H, Yao Y, Guo Z, Xie W. Laparoscopic radical cystectomy with orthotopic ileal neobladder for bladder cancer: oncologic results of 171 cases with a median 3-year follow-up. European urology. 2010; 58(3):442-9. https://doi.org/10.1016/j.eururo.2010.05.046

PMid:20554372

Published

2018-09-23

How to Cite

1.
Wayan Y, Ayu PD, Gde OAA, Wayan N, Widyadharma IPE. Pathological Profile, Early Complications, Functional and Oncological Outcome after Radical Cystectomy - Ileal Conduit for Bladder Cancer Patients in Sanglah General Hospital between January 2013 and December 2016. Open Access Maced J Med Sci [Internet]. 2018 Sep. 23 [cited 2024 Mar. 29];6(9):1647-51. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.384

Issue

Section

B - Clinical Sciences

Most read articles by the same author(s)

1 2 > >>