Elevated High-Sensitivity C-Reactive Protein And Interleukin-6 Plasma As Risk Factors For Symptomatic Lumbar Osteoarthritis In Postmenopausal Women


  • I Ketut Suyasa Department of Orthopaedic and Traumatology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • Anak Agung Wiradewi Lestari Clinical Pathology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • I Gusti Ngurah Yudhi Setiawan Department of Neurosurgery, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • Tjokorda Gde Bagus Mahadewa Department of Neurosurgery, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • I Putu Eka Widyadharma Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia http://orcid.org/0000-0002-4554-0348




low back pain, hs-CRP, ESR, IL-6


AIM: To determine whether elevated high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and erythrocyte sedimentation rate (ESR), as risk factors of symptomatic lumbar osteoarthritis (OA) in estrogen deficiency postmenopausal women.

METHODS: A case-control study was conducted between January and June 2017. The inclusion criteria include post-menopausal women with estrogen deficiency with low back pain. Exclusion criteria were: patients with a history of undergoing bilateral oophorectomy, taking hormonal replacement therapy or corticosteroid, malignancies, and lumbosacral spine trauma. The blood examinations were taken to measure IL-6 level by ELISA, hs-CRP level by spectrophotometry and ESR by modified Westergren method.

RESULTS: A group of 44 pairs of subjects were divided equally into case and control groups showed that in estrogen deficiency postmenopausal women, an increased level of hs-CRP increased the risk for symptomatic lumbar OA (OR = 2.83, CI95% = 1.065-8.776, p = 0.034). Also, a high level of IL-6 increased the risk of symptomatic lumbar OA (OR = 2.7, CI95% = 0.991-8.320, p = 0.033). No such significant findings were found for an increased ESR level.

CONCLUSION: Elevated level of plasma hs-CRP and IL-6 were concluded as risk factors for symptomatic lumbar OA in post-menopausal women.


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How to Cite

Suyasa IK, Lestari AAW, Setiawan IGNY, Mahadewa TGB, Widyadharma IPE. Elevated High-Sensitivity C-Reactive Protein And Interleukin-6 Plasma As Risk Factors For Symptomatic Lumbar Osteoarthritis In Postmenopausal Women. Open Access Maced J Med Sci [Internet]. 2018 Nov. 23 [cited 2022 May 19];6(11):2107-10. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.422



B - Clinical Sciences

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