Probiotics Improve Urogenital Health in Women

Authors

  • Andrea Ballini Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, Bari
  • Luigi Santacroce Ionian Department, University of Bari “Aldo Moro”, Bari, Italy; Polypheno srl - Academic Spin Off, University of Bari “Aldo Moro”, Bari http://orcid.org/0000-0001-5671-8124
  • Stefania Cantore Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, Bari, Italy; Polypheno srl - Academic Spin Off, University of Bari “Aldo Moro”, Bari
  • Lucrezia Bottalico Polypheno srl - Academic Spin Off, University of Bari “Aldo Moro”, Bari
  • Gianna Dipalma Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, Bari
  • Danila De Vito Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, Bari
  • Rajiv Saini Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, Bari
  • Francesco Inchingolo Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, Bari

DOI:

https://doi.org/10.3889/oamjms.2018.406

Keywords:

Hyperbiotics Pro-Women, UTI, Vaginal mucosa, Vaginal microbiota, Nutraceutics

Abstract

BACKGROUND: Urogenital recurrent infections represent a global medical issue in the world, affecting millions of women because of dramatic shifts in bacterial composition and concentrations in response to numerous endogenous and exogenous factors. Urogenital microbiota forms a mutually beneficial relationship with their host and has a major impact on health and disease.

AIM: This study aimed to compare probiotic therapy versus placebo in Oxidative Stress Values (OSVs) and histological features in urogenital infections in female patients.

METHODS: Forty (n = 40) patients diagnosed with recurrent urogenital infections were recruited to be treated as test group (n = 20), receiving Probiotics, and a control group (n = 20), receiving looking similar placebo, both for 90 days. Both the groups were assessed for total oxidant capacity (d-ROMs test) and biological antioxidant potential as iron-reducing activity (BAP test) at baseline, after 1 and 3 months. Histological changes on inner vaginal mucosa were also investigated, during the entire study.

RESULTS: d-ROM assay clearly showed that the values of the test group were significantly different, thus leading the general health conditions from a state of high oxidative stress to low oxidative stress levels. Increasing of BAP values were more significant, and clinically relevant, in probiotic test group over time.

CONCLUSION: Our pilot study gave interesting and promising elements to confirm the safety and effectiveness of oral probiotics in preventing/reducing the recurrent urogenital infections by an overall modification of inner vaginal microbiota.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Skerk V, Markotić A. Urogenital infections--antimicrobial treatment. Med Glas (Zenica). 2010; 7(1):1-11.

Reid G, Bruce AW. Urogenital infections in women: can probiotics help? Postgrad Med J. 2003; 79(934):428-432. https://doi.org/10.1136/pmj.79.934.428 PMid:12954951 PMCid:PMC1742800

Foxman B, Barlow R, D'Arcy H, et al. Urinary tract infection: self-reported incidence and associated costs. Ann Epidemiol. 2000; 10:509–15. https://doi.org/10.1016/S1047-2797(00)00072-7

Cicinelli E, Ballini A, Marinaccio M, Poliseno A, Coscia MF, Monno R, De Vito D. Microbiological findings in endometrial specimen: our experience. Arch Gynecol Obstet. 2012; 285(5):1325-9. https://doi.org/10.1007/s00404-011-2138-9 PMid:22113463

Perrotta C, Aznar M, Mejia R, Albert X, Ng CW. Oestrogens for preventing recurrent urinary tract infection in postmenopausal women. Cochrane Database Syst Rev. 2008; 16(2):CD005131. https://doi.org/10.1002/14651858.CD005131.pub2

Giudice G, Cutrignelli DA, Sportelli P, Limongelli L, Tempesta A, Gioia GD, Santacroce L, Maiorano E, Favia G. Rhinocerebral Mucormycosis with Orosinusal Involvement: Diagnostic and Surgical Treatment Guidelines. Endocr Metab Immune Disord Drug Targets. 2016;16(4):264-269. https://doi.org/10.2174/1871530316666161223145055 PMid:28017141

John AS, Mboto CI, Agbo B. A review of the prevalence and predisposing factors responsible for urinary tract infection among adults. Euro J Exp Bio. 2016; 6(4):7-11.

Hanson L, VandeVusse L, Jermé M, Abad CL, Safdarv N. Probiotics for Treatment and Prevention of Urogenital Infections in Women: A Systematic Review. J Midwifery Womens Health. 2016; 61(3):339-55. https://doi.org/10.1111/jmwh.12472 PMid:27218592

Marrelli M, Tatullo M, Dipalma G, Inchingolo F. Oral infection by Staphylococcus aureus in patients affected by White Sponge Nevus: a description of two cases occurred in the same family. Int J Med Sci. 2012; 9(1):47-50. https://doi.org/10.7150/ijms.9.47 PMid:22211089

Reid G, Beuerman D, Heinemann C, Bruce AW. Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora. FEMS Immunol Med Microbiol. 2001; 32(1):37-41. https://doi.org/10.1111/j.1574-695X.2001.tb00531.x PMid:11750220

Reid G, Bruce AW. Selection of Lactobacillus strains for urogenital probiotic applications. J Infect Dis. 2001; 1(183):S77–S80. https://doi.org/10.1086/318841 PMid:11171021

Reid G, Bruce AW, Taylor M. Influence of three-day antimicrobial therapy and lactobacillus vaginal suppositories on recurrence of urinary tract infections. Clin Ther. 1992; 14(1):11-6. PMid:1576619

Reid G, Bruce AW, Fraser N, Heinemann C, Owen J, Henning B. Oral probiotics can resolve urogenital infections. FEMS Immunol Med Microbiol. 2001; 30(1):49–52. https://doi.org/10.1111/j.1574-695X.2001.tb01549.x PMid:11172991

Tatullo M, Marrelli M, Scacco S, Lorusso M, Doria S, Sabatini R, Auteri P, Cagiano R, Inchingolo F. Relationship between oxidative stress and "burning mouth syndrome" in female patients: a scientific hypothesis. Eur Rev Med Pharmacol Sci. 2012; 16(9):1218-21. PMid:23047505

Ballini A, Santacroce L, Cantore S, Bottalico L, Dipalma G, De Vito D, Gargiulo C, Saini R, Inchingolo F. Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Controlled Pilot Study. Endocr Metab Immune Disord Drug Targets. 2018 (in press). PMid:29692270

Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardization method of Gram stain interpretation. J Clin Microbiol. 1991; 29(2);297–301. PMid:1706728 PMCid:PMC269757

Tatullo M, Simone GM, Tarullo F, Irlandese G, Vito D, Marrelli M, Santacroce L, Cocco T, Ballini A, Scacco S. Antioxidant and Antitumor Activity of a Bioactive Polyphenolic Fraction Isolated from the Brewing Process. Sci Rep. 2016; 27(6):36042. https://doi.org/10.1038/srep36042 PMid:27786308 PMCid:PMC5081531

Belge Kurutas E, Ciragil P, Gul M, Kilinc M. The Effects of Oxidative Stress in Urinary Tract Infection. Mediators Inflamm. 2005; 2005(4):242-244. https://doi.org/10.1155/MI.2005.242

PMid:16192676 PMCid:PMC1526480

Ballini A, Cantore S, Fatone L, Montenegro V, De Vito D, Pettini F, Crincoli V, Antelmi A, Romita P, Rapone B, Miniello G, Perillo L, Grassi FR, Foti C. Transmission of non-viral sexually transmitted infections and oral sex. J Sex Med. 2012; 9(2):372-84. https://doi.org/10.1111/j.1743-6109.2011.02515.x PMid:22023797

Raz R. Hormone replacement therapy or prophylaxis in postmenopausal women with recurrent urinary tract infection. J Infect Dis. 2001; 183(1):S74–6. https://doi.org/10.1086/318842 PMid:11171020

Anukam KC, Osazuwa E, Osemene GI, Ehigiagbe F, Bruce AW, Reid G. Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis. Microbes Infect. 2006; 8(12-13):2772-2776. https://doi.org/10.1016/j.micinf.2006.08.008 PMid:17045832

Pascual L, Ruiz F, Giordano W, Barberis I. Vaginal colonization and activity of the probiotic bacterium Lactobacillus fermentum L23 in a murine model of vaginal tract infection. J Med Microbiol. 2009; 59(3):360-364. https://doi.org/10.1099/jmm.0.012583-0 PMid:19926731

Atassi F, Brassart D, Grob P, Graf F, Servin AL. Lactobacillus strains isolated from the vaginal microbiota of healthy women inhibit Prevotella bivia and Gardnerella vaginalis in coculture and cell culture. FEMS Immunol Med Microbiol. 2006; 48(3):424-432. https://doi.org/10.1111/j.1574-695X.2006.00162.x PMid:17059467

Gil NF, Martinez RC, Gomes BC, Nomizo A, De Martinis EC. Vaginal lactobacilli as potential probiotics against Candida spp. Braz J Microbiol. 2010; 41(1):6-14. https://doi.org/10.1590/S1517-83822010000100002 PMid:24031455 PMCid:PMC3768620

Published

2018-10-19

How to Cite

1.
Ballini A, Santacroce L, Cantore S, Bottalico L, Dipalma G, De Vito D, Saini R, Inchingolo F. Probiotics Improve Urogenital Health in Women. Open Access Maced J Med Sci [Internet]. 2018 Oct. 19 [cited 2021 Apr. 12];6(10):1845-50. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.406

Issue

Section

B - Clinical Sciences

Most read articles by the same author(s)