Correlation between Serum Brain-Derived Neurotrophic Factor Level and Depression Severity in Psoriasis Vulgaris Patients

Authors

  • Muhammad Sjahrir Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr Mansur Kampus USU Medan 20155, Indonesia
  • Irma Damayanti Roesyanto-Mahadi Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr Mansur Kampus USU Medan 20155, Indonesia
  • Elmeida Effendy Psychiatry Department, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr Mansur Kampus USU Medan 20155, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.142

Keywords:

Psoriasis vulgaris, Brain-derived neurotrophic factor, Depression

Abstract

BACKGROUND: Psoriasis vulgaris is a chronic inflammatory skin disorder that can lead to depression. There is a similarity in neurotrophic substance in the pathogenesis of psoriasis and depression; it’s called brain-derived neurotrophic factor (BDNF). BDNF level imbalance potentially affects the severity of psoriasis and depression.

AIM: This study aims to know the correlation between serum BDNF level and depression severity in psoriasis vulgaris patient and also the correlation between serum BDNF level and psoriasis vulgaris severity.

METHODS: This is an analytical cross-sectional study that 23 psoriasis vulgaris patients participated. All participants have performed serum BDNF level examination with enzyme-linked immunosorbent assay (ELISA). Depression severity assessed with Beck depression inventory-II (BDI-II) and psoriasis severity assessed with psoriasis area and severity index. Correlation between all variables was analysed with Spearman’s correlation test.

RESULTS: Serum BDNF level and depression severity are a strongly negative correlation in psoriasis vulgaris patients (r = -0.667 with significant value p = 0.001). There is a moderate negative correlation between serum BDNF level with psoriasis vulgaris severity (r = -0.595 with significant value p = 0.003).

CONCLUSION: In psoriasis vulgaris patients, a low level of serum BDNF may increase depression severity and psoriasis vulgaris severity.

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References

Gudjonson JE, Elder JT. Psoriasis. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editor. Fitzpatrick's dermatology in general medicine. 8th Ed. New york: Mcgraw Hill Companies Inc., 2012:197 – 231.

Botchkarev VA et al. Neurotrophin in skin biology and pathology. Journal of investigative dermatology. 2006; 126:1719–1727. https://doi.org/10.1038/sj.jid.5700270 PMid:16845411

Katzung BG, Masters SB, Trevor AJ. Farmakologi Dasar dan Klinik. 12th edition. Jakarta: EGC, 2014:199 – 209.

Raychaudhuri SP, Farber EM. Neuroimmunologic aspects of psoriasis. Cutis. 2000; 66:357–362. PMid:11107521

Reich A, Orda A, Wis´nicka B, Szepietowski JC. Plasma neuropeptides and perception of pruritus in psoriasis. Acta Derm Venereol. 2007; 87:299–304. https://doi.org/10.2340/00015555-0265 PMid:17598031

Timmusk T, et al. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron. 1993; 10:475–489. https://doi.org/10.1016/0896-6273(93)90335-O

Bath KG, Schilit A, Lee FS. Stress effects on BDNF expression: effects of age, sex, and form of stress. Neuroscience. 2013; 239:149-156. https://doi.org/10.1016/j.neuroscience.2013.01.074 PMid:23402850

Meffert J. Psoriasis [internet]. USA: [publisher unknown]; [date unknown] [2015 January 22; cited 2016 Juli 3]. Available from: http://emedicine.medscape.com/article/1943419-overview

Schmitt J, Ford DE. Understanding the relationship between obejctive disease severity, psoriatic symptoms, illness-related stress, health-related quality of life and depressive symptoms in patients with psoriasis – a structural equations modeling approach. Gen Hosp Psychiatry. 2007; 29(2):134-140. https://doi.org/10.1016/j.genhosppsych.2006.12.004 PMid:17336662

Griffiths CE, Barker JN. Psoriasis. dalam: Burns T, Breathnach SM, Cox NH, Griffiths CE, editor. Rook's textbook of dermatology. Edisi ke-8. UK:Wiley Blackwell, 2010:20.1-60.

Ibrahim G, Waxman R, Helliwell PS. The prevalence of psoriatic arthritis in people with psoriasis. Arthritis and Rheumatism. 2009; 61(10):1373-8. https://doi.org/10.1002/art.24608 PMid:19790120

Kundacki N, Ursen UT, Babiker MO, Urgey EG. The evaluation of the sociodemographic and clinical features of turkish psoriasis patients. International journal of dermatology. 2002; 59(1):19-24.

Fatthy H, Tawfik AA, Madbouly N. Evaluation of serum brain-derived neurotrophic factor to assess the association between psoriasis and depression. J Egypt Women Dermatol. 2015; 12:186–190. https://doi.org/10.1097/01.EWX.0000466467.93686.0d

Mukaka MM. A guide to approriate use of correlation coefficient in medical research. Malawi Med J. 2012; 24(3):69-71. PMid:23638278 PMCid:PMC3576830

Duclot F, Kabbaj M. Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. J Exp Biol. 2015; 218:21-31. https://doi.org/10.1242/jeb.107086 PMid:25568448 PMCid:PMC4286703

Yu H, Chen Z. The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol. 2011; 32:3–11. https://doi.org/10.1038/aps.2010.184 PMid:21131999 PMCid:PMC4003317

Narbutt J, Olejniczak I, Sztychny SD, Jedrzejowska SA, Kwiatkowska SI, Hawro T, et al. Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients. Arch Dermatol Res. 2013; 305:191–195. https://doi.org/10.1007/s00403-012-1293-6 PMid:23108364 PMCid:PMC3606511

Raap U, Werfel T, Goltz C, Deneka N, Langer K, Bruder M, et al. Circulating levels of brain-derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis. Allergy. 2006; 61:1416–1418. https://doi.org/10.1111/j.1398-9995.2006.01210.x PMid:17073871

Published

2019-02-25

How to Cite

1.
Sjahrir M, Roesyanto-Mahadi ID, Effendy E. Correlation between Serum Brain-Derived Neurotrophic Factor Level and Depression Severity in Psoriasis Vulgaris Patients. Open Access Maced J Med Sci [Internet]. 2019 Feb. 25 [cited 2021 Oct. 19];7(4):583-6. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.142

Issue

Section

B - Clinical Sciences

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