Association of Inflammation Mediator in Mucosal and Tissue of Chronic Rhinosinusitis with Recurrent Nasal Polyp


  • Effy Huriyati Postgraduate Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia
  • Eryati Darwin Department of Histology, Faculty of Medicine, Andalas University, Padang Indonesia
  • Yanwirasti Yanwirasti Department of Anatomy, Faculty of Medicine, Andalas University, Padang, Indonesia
  • Irza Wahid Department of Internal Medicine, Faculty of Medicine, Andalas University, General Hospital of Dr M. Djamil, Padang, Indonesia



CRSwNP recurrent, Interleukin-5, Interleukin-8, Interleukin-17A, TGF-β1


BACKGROUND: Chronic rhinosinusitis with polyps (CRSwNP) have a high risk of recurrence and patients often experience repeated surgery. There are several types of inflammatory patterns in CRSwNP, such as Th2 inflammation (eosinophilic) and Th1/Th17 inflammation (neutrophilic).

AIM: This study aims to determine the expression of IL-5, IL-8, IL-17A and TGF-β in recurrent CRSwNP using the most convenient and non-invasive examination tool such as brushing the mucosal polyp and find out its correlation with polyp tissues.

MATERIAL AND METHODS: A cross-sectional comparative study was carried out on 15 samples of mucosal brushing and polyp tissue. Expressions of IL-5, IL-8, IL-17A and TGF-β on mucosa were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) examination and tissues using Immunohistochemical (IHC) examination.

RESULT: The result showed that Only IL-5 has a significant relationship between mucosa and tissue with moderate positive correlation (p < 0.05; r = 0.527).

CONCLUSION: This study concluded that mucosa brushing could be used as a simple and non-invasive examination to observe the expression of IL-5 in recurrent CRSwNP. IL-5 is one of the cytokines that mark the Th2 (eosinophilic) inflammatory pattern where eosinophilic polyps are closely related to recurrence.


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How to Cite

Huriyati E, Darwin E, Yanwirasti Y, Wahid I. Association of Inflammation Mediator in Mucosal and Tissue of Chronic Rhinosinusitis with Recurrent Nasal Polyp. Open Access Maced J Med Sci [Internet]. 2019 May 29 [cited 2024 May 26];7(10):1635-40. Available from:



B - Clinical Sciences

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