Correlation between Estrogen Levels with Lipid Profile in Menopause Women in West Sumatera
DOI:
https://doi.org/10.3889/oamjms.2019.627Keywords:
Menopause, total cholestrol, LDL, HDL, Triglycerida, EstrogenAbstract
BACKGROUND: Menopause is a condition where women had not experienced menstruation for 12 consecutive cycles. At menopause period, there is alteration in women reproductive cycle where estrogen decreased and lipid status altered.
AIM: This study is aimed to understand the association of estrogen level and lipid status in menopause women.
METHODS: This study was an observational study with cross-sectional design underwent in Obstetrics and Gynecology Polyclinic Dr M. Djamil Hospital, Padang to examine estrogen level and lipid level in 107 menopause women aged between 40-60 years old. The study was conducted for 6 months. The relationship between estrogen level and lipid profile was done using correlation test and p-value < 0.05 is significant.
RESULTS: There was no significant correlation between estrogen and total cholesterol (p = 0.146), LDL (p = 0.496), HDL (p = 0.172) and triglyceride (p = 0.296) in menopause women. There was negative correlation between estrogen with total cholesterol (r = -0.141; p = 0.146), HDL (r = -0.133; p = 0.172) and triglyceride (r = -0.1; p = 0.296) and a little positive correlation with LDL (r = 0.06; p = 0.496). Estrogen levels are not related to total Cholesterol, LDL, HDL, and triglyceride in menopause women
CONCLUSION: Estrogen levels did not correlate with lipid status in menopause women in West Sumatera.
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Fritz MA, L Speroff. Clinical gyecologic endocrinology and infertility. 8th ed. Lippincott Williams & Wilkins. Philadelphia, 2011.
Kemenkes RI. Analisis lansia di Indonesia. Pusat Data dan Informasi, 2017.
Prawirohardjo S. Ilmu kandungan. Edisi kedua. PT Bina Pustaka Sarwono Prawirohardjo. Jakarta, 2009.
Siregar MFG. Perimenopausal and post-menopausal complaints in paramedics assessed by menopause rating scale in Indonesia. IOSR-JDMS. 2014; 13(12):38-42. https://doi.org/10.9790/0853-131213842
Dennerstein L, EC Dudley, JL Hopper, JR Gutherie, HG Burger. A prospective population-based study of menopausal symptoms. Obstetrics & Gynecology. 2000; 96(3):351-358. https://doi.org/10.1097/00006250-200009000-00007 PMid:10960625
Sherman S, Miller H, Nerukar L, et al. NIH State of the science conference on management of menopause-related symptoms. Am J Med. 2005; 118(suppl 2):1-172.
Cohen LS, Soares CN, Vitonis AF, Otto MW, Harlow BL. Risk for new onset of depression during the menopausal transition: the harvard study of moods and cycles. Arch Gen Psychiatry. 2006; 63(4):385-390. https://doi.org/10.1001/archpsyc.63.4.385 PMid:16585467
Randolph JF Jr, Zheng H, Sowers MR, et al. Change in follicle-stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period. J Clin Endocrinol Metab. 2011; 96(3):746-754. https://doi.org/10.1210/jc.2010-1746 PMid:21159842 PMCid:PMC3047231
Berg G, Mesch V, Boero L, Sayegh F, Prada M, Royer M, Muzzio ML, Schreier L, Siseles N, Benencia H. Lipid and lipoprotein profile in menopausal transition. Effects of hormones, age and fat distribution. Horm Metab Res. 2004; 36(4):215-220. https://doi.org/10.1055/s-2004-814450 PMid:15114519
Lamarche B, Lemieux I, Despres JP. The small, dense LDL phenotype and the riskof coronary heart disease: epidemiology, patho-physiology and therapeuticaspects. Diabetes Metab. 1997; 25:199-211.
Chatterjee C, Sparks DL. Hepatic lipase, high density lipoproteins, and hypertriglyceridemia. Am J Pathol. 2011; 178(4):1429-1433. https://doi.org/10.1016/j.ajpath.2010.12.050 PMid:21406176 PMCid:PMC3078429
Nagashima K, Yamasawa I, Kamohara S, et al. Changes regarding age and correlations between serum lipids and body mass index in humankind. Methods Inf Med. 2002; 41(4):202-8. https://doi.org/10.1055/s-0038-1634435 PMid:12162143
Stevenson JC, David Crook, Ian F. Godsland. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis. 1993; 98(1):83-90. https://doi.org/10.1016/0021-9150(93)90225-J
Mesalic L, Emir T, Sulejman K, Devleta B. Correlation between hormonal and lipid status in women in menopause. Bosnian Journal of Basic Medical Sciences. 2008; 8(2):188-192. https://doi.org/10.17305/bjbms.2008.2980 PMid:18498273 PMCid:PMC5698353
D. De aloysio, et al. The effect of menopause on blood lipid and lipoprotein levels. Atherosclerosis. 1999; 147 (1):147-153. https://doi.org/10.1016/S0021-9150(99)00315-9
Berg GA, Siseles N, Gonzalez AI, Ortiz OC, Tempone A, Wikinski RW. Higher values of hepatic lipase activity in postmenopause: relationship with atherogenicintermediate density and low density lipoproteins. Menopause. 2001; 8(1):51-7. https://doi.org/10.1097/00042192-200101000-00009 PMid:11201516
Y Cui, X Ruan, J Jin, F Jin, S Brucker, AO Mueck. The pattern of lipids and lipoproteins during the menopausal transition in Chinase women. Climacteric. 2016; 19(3):292-8. https://doi.org/10.3109/13697137.2015.1130694 PMid:26822882
Swarnalatha PK, Ebrahim NKC. A correlative study of estrogen and lipid profile in premenopausal and postmenopausal women. International Journal of Biomedical and Advance Research. 2012; 3(11):818-822. https://doi.org/10.7439/ijbar.v3i11.766
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Ariadi Ariadi, Jamsari Jamsari, Yanwirasti Yanwirasti, Muhammad Fidel Ganis Siregar, Yusrawati Yusrawati (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0
