Macadamia Nuts Oil in Nanocream and Conventional Cream as Skin Anti-Aging: A Comparative Study

Authors

  • Tengku Ismanelly Hanum Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia; Nano Medicine Center, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia
  • Lia Laila Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Sumaiyah Sumaiyah Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Elvi Syahrina Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.533

Keywords:

Anti-aging, cream, macadamia nuts oil, nanocream

Abstract

BACKGROUND: The effect of an active substance in a dosage form can be influenced by the different method of preparation. Nanotechnology has been used widely in all aspects including drug delivery system. Nanocream is one of the cosmetic dosage forms to improve the absorption of active substances on the skin.

AIM: The study was to compare macadamia nuts oil nanocream with conventional cream as skin antiaging dosage form.

METHODS: The formulation of nanocream was consisted of macadamia nuts oil 10%, tween 80, propylene glycol, cetyl alcohol, methyl paraben, propyl paraben and distilled water. The anti-aging was conducted by comparing the nanocream and conventional cream. The evaluation of anti-aging activity was conducted using skin analyzer apparatus. The aging parameters were moisture, evenness, pore size, black spot, and wrinkle of the skin. The data were collected for 4 weeks. All the data obtained were statistically analyzed.

RESULTS: Macadamia nut oil nanocream dosage form showed better antiaging activity on the skin compared to conventional cream which were characterized by changes in skin condition on each aging skin parameter such as water content, pore size, melanin, and wrinkles.

CONCLUSION: It is concluded that macadamia nuts oil in nanocream dosage form has better antiaging activity on the skin compared to conventional cream and macadamia nuts oil can be used as an effective skin anti-aging dosage form.

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Published

2019-11-14

How to Cite

1.
Hanum TI, Laila L, Sumaiyah S, Syahrina E. Macadamia Nuts Oil in Nanocream and Conventional Cream as Skin Anti-Aging: A Comparative Study. Open Access Maced J Med Sci [Internet]. 2019 Nov. 14 [cited 2021 May 9];7(22):3917-20. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.533

Issue

Section

Herbal Medicine in Pharmaceutical and Clinical Sciences

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