The Difference of sVE-Cadherin Levels between Dengue Hemorrhagic Fever Patients with Shock and without Shock

Rinang Mariko; Eryati Darwin; Yanwirasti Yanwirasti; Sri Rezeki Hadinegoro

doi:10.3889/oamjms.2019.602

Authors

Rinang Mariko Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Pediatrics, Faculty of Medicine, Andalas University, General Hospital of Dr M. Djamil, Padang, Indonesia
Eryati Darwin Department of Histology, Faculty of Medicine, Andalas University, Padang, Indonesia
Yanwirasti Yanwirasti Department of Anatomy, Faculty of Medicine, Andalas University, Padang, Indonesia
Sri Rezeki Hadinegoro Department of Pediatrics, Faculty of Medicine, Indonesia University, Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.602

Keywords:

sVE-Cadherin, Dengue Hemorrhagic Fever (DHF), Shock

Abstract

BACKGROUND: Dengue virus infection is an infectious disease caused by the dengue virus and transmitted by the Aedes aegypti mosquito. Dengue virus (DEN-V) consists of 4 serotypes, namely DEN-1, DEN-2, DEN-3, and DEN-4. The most feared result of DHF is death. Death in children is caused by hypovolemic shock due to plasma leakage from intravascular to extravascular space due to endothelial dysfunction.

AIM: This study aims to analyse difference in sVE-Cadherin levels in Dengue Hemorrhagic Fever (DHF) with and without shock.

MATERIAL AND METHODS: The method of taking samples is consecutive sampling, namely the research subjects obtained based on the order of entry in the hospital with a comparative cross-sectional design. From the results of the calculation using the sample formula, the sample size for each group is set at 32 people. So that the total sample size used for both groups is 64 people. The serum sVE-Cadherin levels using the ELISA method. The statistical test used is the independent t-test. The value of p < 0.05 was said to be statistically significant.

RESULTS: The result showed that there was no difference in mean sVE-Cadherin levels between DHF patients with shock and without shock (p > 0.05).

CONCLUSION: This study concluded that there was no difference in mean of sVE-Cadherin level in DHF patients with shock and without shock.