Pentraxin 3: A Potential Novel Predictor for Neonatal Pulmonary Hypertension

Authors

  • Maged A. El Wakeel National Research Centre, Child Health Department, Giza, Egypt
  • Rania N. Sabry National Research Centre, Child Health Department, Giza, Egypt
  • Ghada M. El-kassas National Research Centre, Child Health Department, Giza, Egypt
  • Shereen A. Abd El-Gaffar El-Galaa Maternity Teaching Hospital - Pediatric, Cairo, Egypt
  • Wael H. El batal National Research Centre, Child Health Department, Giza, Egypt
  • Essam M. Galal National Research Centre, Child Health Department, Giza, Egypt
  • Ashraf Azmy National Research Centre, Child Health Department, Giza, Egypt
  • Eman Awadallah National Research Centre - Clinical and Chemical Pathology, Giza, Egypt

DOI:

https://doi.org/10.3889/oamjms.2019.638

Keywords:

Pentraxin 3, Pulmonary hypertension, Neonates, Congenital heart disease

Abstract

BACKGROUND: Persistent pulmonary hypertension of the newborn (PPHN) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation. Pentraxin 3 is one of the long pentraxins, which plays an essential role in regulation of cell proliferation and angiogenesis.

AIM: This study aims to assess serum pentraxin 3 levels in neonates with pulmonary arterial hypertension and compare them in those who have other congenital heart diseases and healthy neonates. Also, we intended to evaluate serum levels of CRP as a mediator of inflammation in the studied groups.

METHODS: The study is a case-control study. Cases were recruited from El Galaa Teaching Hospital, classified into three groups; each group had thirty cases. The first one: cases with pulmonary hypertension (PHT), the second one: cases with congenital heart diseases (CHD) without pulmonary hypertension and the third group included healthy neonates. All participants were subjected to full history taking and full clinical examination. Diagnosis of congenital heart disease and pulmonary hypertension was made according to echocardiographic ï¬ndings by pediatric cardiologist using echocardiography machine. Laboratory investigations included measurement of serum pentraxin 3, Routine CBC, CRP.

RESULTS: This study found that the mean serum pentraxin 3 in PHT neonates was significantly higher than that of the control and CHD neonates (p ≤ 0.001, p = 0.02 respectively). Also, the mean Pentraxin3 of the CHD neonates was significantly higher than that of the control (p = 0.06). Also, the mean CRP of the PHT neonates was significantly higher than that of the control (p = 0.01). Regression analysis showed that Pentraxin3 was the main predictor of PAP (P = 0.01).

CONCLUSION: Serum pentraxin 3 is significantly elevated in neonates with pulmonary hypertension, so measurement of pentraxin 3 levels in neonates may be valuable as a predictor for pulmonary hypertension in neonates.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

Published

2019-08-14

How to Cite

1.
El Wakeel MA, Sabry RN, El-kassas GM, Abd El-Gaffar SA, El batal WH, Galal EM, Azmy A, Awadallah E. Pentraxin 3: A Potential Novel Predictor for Neonatal Pulmonary Hypertension. Open Access Maced J Med Sci [Internet]. 2019 Aug. 14 [cited 2022 May 27];7(15):2424-7. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.638

Issue

Section

B - Clinical Sciences

Most read articles by the same author(s)

1 2 > >> 

Similar Articles

You may also start an advanced similarity search for this article.