Correlation of Troponin Level (Troponin T, Troponin I) With PELOD-2 Score in Sepsis as a Predictive Factor of Mortality

Authors

  • Aileen Clarissa Dauhan Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Aridamuriany D. Lubis
  • Erna Mutiara Faculty of Public Health, Universitas Sumatera Utara, Medan, Indonesia
  • Munar Lubis Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.806

Keywords:

Troponin, PELOD-2, Sepsis, Mortality

Abstract

BACKGROUND: Sepsis in children with cardiovascular involvement can increase mortality. Recently, many studies have been conducted to investigate troponin as an early marker of myocardial dysfunction, associated with pediatric sepsis score. Pediatric Logistic Organ Dysfunction 2 (PELOD-2) score is recent scoring to assess organ dysfunction in sepsis children.

AIM: To determine the correlation between troponin T, troponin I with PELOD-2 score in sepsis as a predictive factor of mortality.

METHODS: A prospective cohort study was conducted on sepsis children in PICU Haji Adam Malik General Hospital, Medan. Assessment of PELOD-2 score, serum troponin T, and troponin I levels performed on the first day and 48 hours after sepsis was diagnosed. Patients were observed until moved to the ward or died.

RESULTS: A group of 41 subjects were recruited in this study. Troponin T level at 24 hours did not correlate with PELOD-2 scores. Troponin T level at 48 hours was positively correlated with PELOD-2 score (r = 0.771, p < 0.001) and had a significant association with the mortality rate (p < 0.001). Troponin T at 48 hours could be used as a predictive factor of mortality (AUC 86.4%, p < 0.001) with a cut-off point of 40.3 ng/mL (76% sensitivity, 75% specificity, RR 2.48). Troponin I levels at 24 and 48 hours also had strong correlation with PELOD-2 score (r = 0.326, p = 0.037; r = 0.691, p < 0.001) and could be used as a predictor of mortality in pediatric patients with sepsis (AUC 74.8%, p 0.008; AUC 92.6%, p < 0.001). The cut-off point of troponin I at 24 hours was 0.075 ng/mL (68% sensitivity, 68.8% specificity, RR 1.84) and at 48 hours was 0.125 ng/mL (80% sensitivity, 81.3% specificity, RR 3.13).

CONCLUSION: Serum troponin T and troponin I levels at 48 hours have positive correlation with PELOD-2 score as a predictive factor of mortality in pediatric patients with sepsis.

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Published

2019-12-13

How to Cite

1.
Dauhan AC, Lubis AD, Mutiara E, Lubis M. Correlation of Troponin Level (Troponin T, Troponin I) With PELOD-2 Score in Sepsis as a Predictive Factor of Mortality. Open Access Maced J Med Sci [Internet]. 2019 Dec. 13 [cited 2024 Apr. 21];7(23):4072-7. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.806

Issue

Section

B - Clinical Sciences

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