The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers

Authors

  • Noni Novisari Soeroso Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155
  • Rozaimah Zain-Hamid Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155, Indonesia; 3Department of Biochemistry, Faculty of Medicine, Gadjah Mada University, Jl. Farmako Sekip Utara, Yogyakarta 55281
  • Bintang Y. M. Sinaga Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155
  • Ahmad Hamim Sadewa Department of Biochemistry, Faculty of Medicine, Gadjah Mada University, Jl. Farmako Sekip Utara, Yogyakarta 55281
  • Tamsil Syafiuddin Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155
  • Elisna Syahruddin Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Jl. Persahabatan Raya No.1, Jakarta 13230
  • Gino Tann Department of Clinical Pathology, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155
  • Erna Mutiara Department of Biostatistics, Faculty of Public Health, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155

DOI:

https://doi.org/10.3889/oamjms.2018.224

Keywords:

Polymorphism of CYP2A6 gene, Nicotine Dependence, Bataknese, Brinkman Index

Abstract

AIM: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers.

METHOD: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia.

RESULTS: Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index.

CONCLUSION: The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants.

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References

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Published

2018-05-19

How to Cite

1.
Soeroso NN, Zain-Hamid R, Sinaga BYM, Sadewa AH, Syafiuddin T, Syahruddin E, Tann G, Mutiara E. The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers. Open Access Maced J Med Sci [Internet]. 2018 May 19 [cited 2024 May 26];6(5):864-6. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.224

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Section

Brief Communication

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