Neoadjuvant Chemotherapy Effect on Predictive Value of Sentinel Lymph Node Biopsy using Single Method Methylene Blue in Breast Cancer Patients at Low-resource Country
DOI:
https://doi.org/10.3889/oamjms.2021.5715Keywords:
Neoadjuvant chemotherapy, Predictive value, Sentinel lymph node biopsy, Methylene blue, Low-resource countryAbstract
AIM: This study aimed to examine the application of neoadjuvant chemotherapy (NAC) effect on sentinel lymph node biopsy (SLNB) using single method methylene blue 1% in breast cancer patients at low-resource country.
METHODS: This analytical observational study employed a retrospective case–control approach. The total sampling method was used by involving the entire population of Stage-I and -II breast cancer patients after performed core biopsy or open biopsy with clinically negative axillary lymph nodes that had performed SLNB and axillary lymph nodes dissection at several hospitals in Surakarta from January to May 2020. The descriptive data were presented in the frequency table. Sensitivity, specificity, positive predictive value, negative predictive value (NPV), and diagnostic values were reported with 95% confidence of interval (CI).
RESULTS: From a total of 161 patients, 100 patients were given NAC. The identification rate of the non-NAC was 91.3% and the NAC group 80.6%. Non-NAC group obtained a false-negative rate of 24.4% with NPV of 94.4% (95% CI 85–100), while the false-negative rate of the NAC group was 10.8% with NPV of 74% (95% CI 65–80).
CONCLUSIONS: NAC with single method methylene blue 1% injection in SLNB can reduce the identification and false-negative rates in breast cancer patients.
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Gradishar WJ, Anderson BO, Abraham J, Aft R, Agnese D, Allison KH, et al. Breast cancer, Version 3.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2020;18(4):452-78. PMid:32259783
Papathemelis T, Jablonski E, Scharl A, Hauzenberger T, Gerken M, Klinkhammer-Schalke M, et al. Sentinel lymph node biopsy in breast cancer patients by means of indocyanine green using the karl storz VITOM® fluorescence camera. Biomed Res Int. 2018;2018:6251468. https://doi.org/10.1155/2018/6251468 PMid:29780827
Ramírez-Nava G, Santos-Cuevas C, Ferro-Flores G, Ocampo- García B, Chairez I, Gómez-Argumosa E, et al. Hybrid (2D/3D) dosimetry of radiolabeled gold nanoparticles for sentinel lymph node detection in patients with breast cancer. Contrast Media Mol Imaging. 2020;2020:2728134. https://doi.org/10.1155/2020/2728134 PMid:32489332
Lee SA, Lee HM, Lee HW, Yang BS, Park JT, Ahn SG, et al. Risk factors for a false-negative result of sentinel node biopsy in patients with clinically node-negative breast cancer. Cancer Res Treat. 2018;50(3):625-33. https://doi.org/10.4143/crt.2017.089 PMid:28759990
Faisal M, Sayed MG, Antonious K, Bakr AA, Farag SH. Prevention of lymphedema via axillary reverse mapping for arm lymph-node preservation following breast cancer surgery: A randomized controlled trial. Patient Saf Surg. 2019;13:35. https://doi.org/10.1186/s13037-019-0217-1 PMid:31807140
Lucci A, McCall LM, Beitsch PD, Whitworth PW, Reintgen DS, Blumencranz PW, et al. Surgical complications associated with sentinel lymph node dissection (SLND) plus axillary lymph node dissection compared with SLND alone in the American college of surgeons oncology group trial Z0011. J Clin Oncol. 2007;25(24):3657-63. https://doi.org/10.1200/jco.2006.07.4062 PMid:17485711
Langer I, Guller U, Berclaz G, Koechli OR, Schaer G, Fehr MK, et al. Morbidity of sentinel lymph node biopsy (SLN) alone versus SLN and completion axillary lymph node dissection after breast cancer surgery: A prospective Swiss multicenter study on 659 patients. Ann Surg. 2007;245(3):452-61. https://doi.org/10.1097/01.sla.0000245472.47748.ec PMid:17435553
Rubio IT. Sentinel lymph node biopsy after neoadjuvant treatment in breast cancer: Work in progress. Eur J Surg Oncol. 2016;42(3):326-32. https://doi.org/10.1016/j.ejso.2015.11.018 PMid:26774943
Mamounas EP, Anderson SJ, Dignam JJ, Bear HD, Julian TB, Geyer CE, et al. Predictors of locoregional recurrence after neoadjuvant chemotherapy: Results from combined analysis of national surgical adjuvant breast and bowel project B-18 and B-27. J Clin Oncol. 2012;30(32):3960-6. https://doi.org/10.1200/jco.2011.40.8369 PMid:23032615
Fan F. Evaluation and reporting of breast cancer after neoadjuvant chemotherapy. Open Pathol J. 2009;3(2):58-63.
Cohen LF, Breslin TM, Kuerer HM. Identification and evaluation of axillary sentinel lymph nodes in patients with breast carcinoma treated with neoadjuvant chemotherapy. Am J Surg Pathol. 2000;24(9):1266-72. https://doi.org/10.1097/00000478-200009000-00010 PMId:10976701
Zurrida S, Veronesi U. Milestones in breast cancer treatment. Breast J. 2015;21(1):3-12. https://doi.org/10.1111/tbj.12361 PMid:25494903
Widodo I, Dwianingsih EK, Triningsih E, Utoro T, Soeripto S. Clinicopathological features of Indonesian breast cancers with different molecular subtypes. Asian Pac J Cancer Prev. 2014;15(15):6109-13. https://doi.org/10.7314/apjcp.2014.15.15.6109 PMid:25124582
Brahma B, Putri RI, Karsono R, Andinata B, Gautama W, Sari L, Haryono SJ. The predictive value of methylene blue dye as a single technique in breast cancer sentinel node biopsy: A study from Dharmais cancer hospital. World J Surg Oncol. 2017;15(1):41. https://doi.org/10.1186/s12957-017-1113-8 PMid:31205300
Borgstein PJ, Meijer S, Pijpers RJ, van Diest PJ. Functional lymphatic anatomy for sentinel node biopsy in breast cancer: Echoes from the past and the periareolar blue method. Ann Surg. 2000;232(1):81-9. https://doi.org/10.1097/00000658-200007000-00012 PMid:10862199
Shimazu K, Tamaki Y, Taguchi T, Takamura Y, Noguchi S. Comparison between periareolar and peritumoral injection of radiotracer for sentinel lymph node biopsy in patients with breast cancer. Surgery. 2002;131(3):277-86. https://doi.org/10.1067/msy.2002.121378 PMid:11894032
Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial. JAMA. 2011;305(6):569-75. https://doi.org/10.1001/jama.2011.90 PMid:21304082
Soebhi T, Yarso KY, Sobri FB, Budhi IB. Methylene blue absorption in sentinel lymph node biopsy for early breast cancer after neoadjuvant chemotherapy. Asian Pac J Cancer Prev. 2020;21(6):1767-71. https://doi.org/10.31557/apjcp.2020.21.6.1767 PMid:32592376
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Copyright (c) 2021 Muhammad David Perdana Putra, Kristanto Yuli Yarso, Brian Wasita (Author)
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