Chronic Obstructive Pulmonary Disease in Never-Smoking Bricklayers


  • Jordan Minov Institute for Occupational Health of Republic of Macedonia, Skopje
  • Jovanka Karadzinska-Bislimovska Institute for Occupational Health of Republic of Macedonia, Skopje
  • Kristin Vasilevska Institute for Epidemiology and Biostatistics, Faculty of Medicine, Ss Cyril and Methodius University of Skopje
  • Snezana Risteska-Kuc Institute for Occupational Health of Republic of Macedonia, Skopje
  • Saso Stoleski Institute for Occupational Health of Republic of Macedonia, Skopje
  • Dragan Mijakoski Institute for Occupational Health of Republic of Macedonia, Skopje



airflow limitation, bronchodilator reversibility testing, occupational exposure, questionnaire, spirometry.


Background: Chronic obstructive pulmonary disease (COPD) due to occupational exposures remains an important public health problem taking significant toll on the global burden of the disease.

Aim: In order to assess chronic prevalence and characteristics of COPD in bricklaying we performed a cross-sectional study including 47 never-smoking male bricklayers (aged 34 to 57 years) and an equal number of never-smoking male office workers studied as a control.

Methods: Evaluation of examined subjects consisted of completion of a questionnaire, baseline spirometry, and bronchodilator reversibility testing.

Results: We found higher prevalence of respiratory symptoms in bricklayers with significant difference for cough and phlegm. Majority of the chronic respiratory symptoms in bricklayers were work-related. The mean values of all measured spirometric parameters in bricklayers were significantly lower than in office workers. The prevalence of COPD was significantly higher in bricklayers than in office workers (14.9% vs. 4.3%, P = 0.034). COPD in both examined groups was close related to age over 45 years, while in bricklayers significant association was registered for duration of occupational exposure longer than 20 years and work-related respiratory symptoms.

Conclusion: Our findings support data about relationship between occupational exposure to inorganic dust and fumes in construction workers and persistent airflow limitation.


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Beclacke MR. Chronic airflow limitations: its relationship to work in dusty occupations. Chest. 1985; 88: 608-617.

Meredith SK, Taylor VM, Mc Donald JC. Occupational respiratory disease in the United Kingdom: a report to the British Thoracic Society and the Society of Occupational Medicine by the SWORD project group. Br I Ind Med. 1991; 48: 292-298.

Blanc PD. Occupation and COPD: a brief review. J Asthma. 2012; 49 (1): 2-4.

Balmes J, Becklake M, Blanc P, Henneberger P, Kreiss K, Mapp C, Milton D, Schwartz D, Toren K, Viegi G. American Thoracic Society Statement: Occupational contribution to the burden of airway disease. Am J Respir Crit Care Med. 2003; 167: 787-797.

Trupin L, Earnest G, San Pedro M, Balmes JR, Eisner MD, Yelin E, Katz PP, Blanc PD. The occupational burden of chronic obstructive pulmonary disease. Eur Respir J. 2003; 22: 462-469.

Hnizdo E, Sullivan PA, Bang KM, Wagner G. Association between chronic obstructive pulmonary disease and employment by industry and occupation in the US population: a study of data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2002; 156: 738-746.

Blanc PD, Menezes AM, Plana E, Mannino DM, Hallal PC, Toren K, Eisner MD, Zock JP. Occupational exposures and COPD: an ecological analysis of international data. Eur Respir J. 2009; 33 (2): 298-304.

Dement JM, Welch L, Ringen K, Bingham E, Quinn P. Airways obstruction among older construction and trade workers at Department of Energy nuclear sites. Am J Ind Med. 2010; 53: 224-240.

Bergdahi IA, Toren K, Eriksson K, Hedlund U, Nilsson T, Flodin R, Jarvholm B. Increased mortality in COPD among construction workers exposed to inorganic dust. Eur Respir J. 2004; 23: 402-406.

Churg A, Hobson J, Wright J. Functional and morphological comparison of silica- and elastine-induced airflow obstruction. Exp Lung Res. 1989; 151: 813-822.

Shore S, Kobzik L, Long NC, Skornik W, Van Staden CJ, Boulet L, Rodger IW, Pon DJ. Increased airway responsiveness in a rat model of chronic bronchitis. Am J Respir Crit Care Med. 1995; 151: 1931-1938.

Harkema JR, Hotchkiss JA. Ozone- and endotoxin-induced mucous metaplasias in rat airway epithelium: novel animal models to study toxicant-induced epithelial transformation in airways. Toxicol Lett. 1993; 68: 251-263.

Bonner JC, Rice AB, Moomaw CR, Morgan DL. Airway fibrosis in rats induced by vanadium pentoxide. Am J Physiol. 2000; 278: L209-L216.

Shapiro SD. Animal models for COPD. Chest. 2000; 117: 2235-2275.

Becklake MR. Occupational exposures: evidence for a causal association with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1989; 140: S85-S91.

Boschetto P, Quintivalle S, Miotto D, Lo Cascio N, Zeni E, Mapp C. Chronic obstructive pulmonary disease (COPD) and occupational exposures. J Occup Med Toxicol. 2006; 1: 11.

Brown JR, Crowden GP. Energy expenditure ranges and muscular work grades. Br J Ind Med. 1963; 20: 277-283.

World Health Organization. Guidelines for controlling and monitoring the tobbaco epidemic. Geneva: WHO, 1998.

Leffondre K, Abrahamowicz M, Siemiatycki J, Rachet B. Modelling smoking history: A comparison of different approaches. Am J Epidemiol. 2002; 156: 813-823.

Spirometry Guide: 2010 Update.

Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CPM, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J. Standardisation of spirometry. Eur Respir J. 2005; 26: 319-338.

Minette A. Questionnaire of the European Community for Coal and Steel (ECSC) on respiratory symptoms. 1987 - updating of the 1962 and 1967 questionnaires for studying chronic bronchitis and emphysema. Eur Respir J. 1989; 2:165-177.

European Community Respiratory Health Survey. Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Respiratory Health Survey (ECRHS). Eur Respir J. 1996; 9: 687-695.

Meijer E, Grobbe DE, Heederik DJJ. Health surveillance for occupational chronic obstructive disease. J Occup Environ Med. 2001; 43: 444-450.

U.S. Department of Health and Human Services. The health consequences of smoking: chronic obstructive pulmonary disease. A report of the Surgeon General. US Department of Health and Human Services, Public Health Service, Office of the Assistant for Health, Office of Smoking and Health. DHHS Publication No. 84-50 205, 1984.

Janson C, Chinn S, Jarvis D, Zock JP, Toren K, Burney P, for the European Community Respiratory Health Survey. Effects of passive smoking on respiratory symptoms, bronchial responsiveness, lung function, and total serum IgE in the European Community Respiratory Health Survey: a cross-sectional study. Lancet. 2001; 358: 2103-2109.

Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J. 1993; 6 (16): 5-40.

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: 2011 Update. Available at:

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: 2010 Update. Available at:

Minov J, Karadzinska-Bislimovska J, Vasilevska K, Risteska-Kuc S, Stoleski S. Exposure to environmental tobacco smoke in the workplace in Macedonia: Where are we now? Arh Hig Rada Toksikol. 2008; 59: 103-109.

Minov J, Karadzinska-Bislimovska J, Vasilevska K, Nelovska Z, Risteska-Kuc S, Stoleski S, Mijakoski D. Smoking among Macedonian workers five years after the anti-smoking campaign. Arh Hig Rada Toksikol. 2012; 63: 207-213.

Weill H, Jones RN, Parkes WR. Silicosis and related diseases. In: Parkes WR, ed. Occupational lung disease. Oxford: Butterworth-Heinemann, 1994:pp 285-339.

American Thoracic Society (ATS). Adverse effects of crystalline silica exposure. Am J Crit Care Med. 1997; 55: 761-765.

Steenland K, Brown D. Silicosis among gold miners: exposure-response analyses and risk assessment. Am J Public Health. 1995; 85: 1372-1377.

Ng TP, Chan SL. Lung function in relation to silicosis and silica exposure in granite workers. Eur Respir J. 1992; 5: 986-991.

Zuskin E, Mustajbegovic J, Schachter EN, Kern J, Doko-Jelinic J, Godnic-Cvar J. Respiratory findings in workers employed in brick-manufacturing industry. J Occup Environ Med. 1998; 40: 814-820.

Meijer E, Krombout H, Heederik D. Respiratory effects of exposure to low levels of concrete dust containing crystalline silica. AM J Ind Med. 2001; 40: 133-140.

Barber CM, Fishwick D. Chronic cough – occupational considerations. Chron Respir Dis. 2008; 5 (4): 211-221.

Rodriguez E, Ferrer J, Marti S, Zock JP, Plana E, Morell F. Impact of occupational exposure on severity of COPD. Chest. 2008; 134 (6): 1237-1243.

Groneberg D, Nowak D, Wussow A, Fischer A. Chronic cough due to occupational factors. J Occup Med Toxicol. 2006; 1:3.

Al-NeaimiYI, Gomes J, Lloyd OL. Respiratory illnesses and ventilatory function among workers at a cement factory in a rapidly developing country. Occup Med. 2001; 51: 367-373.

Love RG, Miller BG. Longitudinal study of lung function in coal miners. Thorax. 1982; 37: 193-197.

Oxman AD, Muir DCF, Shannon HS, Stock SR, Hnizdo E, Lange HJ. Occupational dust exposure and chronic obstructive pulmonary disease. Am Rev Respir Dis. 1993; 148: 38-48.

Seixas NS, Robins TG, Attfield MD, Moulton LH. Longitudinal and cross-sectional analyses of coal mine dust and pulmonary function in new miners. Br J Ind Med. 1993; 50: 929-937.

Hnizdo E, Baskind E, Sluis-Cremer GK. Combined effect of silica dust exposure and tobacco smoking on the prevalence of respiratory impairment among gold miners. Scan J Work Environ Health. 1990; 16: 411-422.




How to Cite

Minov J, Karadzinska-Bislimovska J, Vasilevska K, Risteska-Kuc S, Stoleski S, Mijakoski D. Chronic Obstructive Pulmonary Disease in Never-Smoking Bricklayers. Open Access Maced J Med Sci [Internet]. 2013 Dec. 15 [cited 2021 Apr. 16];1(1):59-65. Available from:



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