Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women
DOI:
https://doi.org/10.3889/oamjms.2014.047Keywords:
Vitamin D, Obesity, cognitive functions, females, insulin resistance.Abstract
OBJECTIVE: To evaluate the levels of serum vitamin D (25-hydroxyvitamin D) among obese Egyptian females and search possible association with cognitive functions and insulin resistance.
SUBJECTS AND METHODS: This study included 2 groups, Group-1(cases) consists of 120 obese females and Group-2 (controls) consists of 30 non-obese females. The included females were subjected to full clinical examination, anthropometric measurements and Kendrick Battery for evaluation of cognitive functions (short term memory and attention). Evaluation of serum Vitamin D, Parathyroid hormone, C-peptide and fasting blood glucose were done. The obese group was put on a balanced low caloric diet (900-1000 K Calories/day) for 2 months, where reevaluation was performed.
RESULTS: Comparing obese group with non-obese control group revealed significant lower mean level of serum vitamin D associated with significant lower cognitive functions test and higher fasting blood glucose. After 2 months of low caloric diet, a significant increase in the serum level of vitamin D, accompanied with improvement in cognitive functions and decrease in fasting blood glucose and improved insulin resistance was seen. A correlation is found between vitamin D serum level and cognitive functions.
CONCLUSION: A lower vitamin D serum level could be a modifiable risk factor for obesity, insulin resistance and cognitive impairment in middle age females.Downloads
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Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010; 170:1135–1141. DOI: https://doi.org/10.1001/archinternmed.2010.173
Llewellyn DJ, Lang IA, Langa KM, Melzer D. Vitamin D and cognitive impairment in the elderly US population. J Gerontol A Biol Sci Med Sci. 2010; 66: 59–65. DOI: https://doi.org/10.1093/gerona/glq185
Maddock J1, Geoffroy MC, Power C, Hyppönen E .25-Hydroxyvitamin D and cognitive performance in mid-life. Br J Nutr. 2013; 18:1-11.
McCann JC, Ames BN.Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 2008; 22(4):982-1001. DOI: https://doi.org/10.1096/fj.07-9326rev
Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 2005; 29:21–30. DOI: https://doi.org/10.1016/j.jchemneu.2004.08.006
Annweiler C, Allali G, Allain P, Bridenbaugh S, Schott AM. Vitamin D and cognitive performance in adults: a systematic review. Eur J Neurol. 2009; 16(10):1083-9. DOI: https://doi.org/10.1111/j.1468-1331.2009.02755.x
Annweiler C, Montero-Odasso M, Llewellyn DJ, Richard-Devantoy S. Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis. 2013; 37(1):147-71. DOI: https://doi.org/10.3233/JAD-130452
Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW.Association of vitamin D deficiency with cognitive impairment in older women: cross-sectional study. Neurology. 2010; 74:27–32. DOI: https://doi.org/10.1212/WNL.0b013e3181beecd3
Gutiérrez-Medina S, Gavela-Pérez T, DomÃnguez-Garrido MN, Blanco-RodrÃguez M, Garcés C, Rovira A, Soriano-Guillén L.[High prevalence of vitamin D deficiency among spanish obese children and adolescents.] An Pediatr (Barc). 2014; 80(4): 229-35.
Kelishadi R, Ardalan G, Motlagh ME, Shariatinejad K, Heshmat R. National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): the CASPIAN-III Study. Nutrition. 2014; 30(1):33-8. DOI: https://doi.org/10.1016/j.nut.2013.05.018
Theuri G, Kiplamai F. Association between vitamin D levels and central adiposity in an eastern Africa outpatient clinical population. Dermatoendocrinol. 2013; 5(1):218-21. DOI: https://doi.org/10.4161/derm.24654
ju-Seo JA, Eun CR, Cho H, Lee SK, Yoo HJ, Kim SG. Low vitamin D status is associated with nonalcoholic Fatty liver disease independent of visceral obesity in Korean adults. PLoS One. 2013; 8(10):e75197. DOI: https://doi.org/10.1371/journal.pone.0075197
Zhou JC1, Zhu YM, Guo P, Chen Z, Xie FZ, Liu XL, He S. Serum 25(OH)D and lipid levels in Chinese obese and normal weight males before and after oral vitamin D supplementation. Biomed Environ Sci. 2013; 26(10):801-7.
Elske M. Brouwer-Brolsma, Edith J. M. Feskens, Wilma T. Steegenga, Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study .Eur J Nutr. 2013; 52(3): 917–925. DOI: https://doi.org/10.1007/s00394-012-0399-0
Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin D in insulin resistance. J Biomed Biotechnol. 2012; 2012: 634195. DOI: https://doi.org/10.1155/2012/634195
Ou HY, Karnchanasorn R, Lee LZ, Chiu KC. Interaction of BMI with vitamin D and insulin sensitivity. Eur J Clin Invest. 2011; 41:1195–1201. DOI: https://doi.org/10.1111/j.1365-2362.2011.02525.x
Gunstad J, Lhotsky A, Wendell CR, Ferrucci L, Zonderman AB. Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging. Neuroepidemiology. 2010; 34(4):222-9. DOI: https://doi.org/10.1159/000297742
Xu WL, Atti AR, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Midlife overweight and obesity increase late-life dementia risk: A population-based twin study. Neurology. 2011;76. DOI: https://doi.org/10.1212/WNL.0b013e3182190d09
Gibson A J and Kindrick DC. The Kendrick battery for the detection of dementia in the elderly. NFER publishing company, 1977.
Barham D., Trinder P. An improved color reagent for determination of blood glucose by oxidase system. Analyst. 1972; 97:142-145. DOI: https://doi.org/10.1039/an9729700142
Field J.B. Hypoglycemia: Definition, clinical presentations, classification and laboratory tests. Endocrinol Metab Clin. North Am. 1989; 18:27-43. DOI: https://doi.org/10.1016/S0889-8529(18)30387-6
Li X, Zhou ZG, Qi HY et al. Replacement of insulin by fasting C-peptide in modified homeostasis model assessment to evaluateinsulin resistance and islet beta cell function. Zhonghua Yi Xue Yi Chuan Xue ZaZhi (Chinese). 2004; 29(4):419–423.
Wielders JP, Wijnberg FA. Preanalytical stability of 25(OH)-vitamin D3 in human blood or serum at room temperature: solid as a rock. Clin Chem. 2009; 55(8):1584-1585. DOI: https://doi.org/10.1373/clinchem.2008.117366
Bouillon R, Coopmans W, De Groote DEH, Radoux D, Eliard PH. Immunoradiometric assay of Parathyrin with polyclonal andmonoclonal region specific antibodies. Clin Chem. 1990; 36(2):271-276. DOI: https://doi.org/10.1093/clinchem/36.2.271
Suárez-MartÃnez EB, Pérez CM, Cruz SK, Khorsandi S, Chardón C, Ferder L. Importance of vitamin D and vitamin D levels status in Puerto Ricans. J Health Care Poor Underserved. 2013; 24(4): 38-47. DOI: https://doi.org/10.1353/hpu.2014.0000
Choi HS, Oh HJ, Choi H, Choi WH, Kim JG, Kim KM, Kim KJ, Rhee Y, Lim SK. Vitamin D insufficiency in Korea: a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008. J Clin Endocrinol Metab. 2011; 96:643–651. DOI: https://doi.org/10.1210/jc.2010-2133
Ardawi MS, Qari MH, Rouzi AA, Maimani AA, Raddadi RM. Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women. Osteoporos Int. 2011; 22(2):463-75. DOI: https://doi.org/10.1007/s00198-010-1249-7
Kang JH, Kim SS, Moon SS, Kim WJ, Bae MJ, Choi BG, Jeon YK, Kim BH, Kim YK, Kim IJ. Adiposity in the Relationship between Serum Vitamin D Level and Insulin Resistance in Middle-Aged and Elderly Korean Adults: The Korea National Health and Nutrition Examination Survey 2008. Endocrinol Metab (Seoul). 2013;28(2):96-102.
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72:690–693. DOI: https://doi.org/10.1093/ajcn/72.3.690
Sergeev IN, Song Q. High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol Nutr Food Res. 2014 Jan 22. DOI: https://doi.org/10.1002/mnfr.201300503
Brouwer-Brolsma EM, van de Rest O, Tieland M .Serum 25-hydroxyvitamin d is associated with cognitive executive function in dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin d with glucose metabolism, cognitive performance and depression. J Am Med Dir Assoc. 2013; 14(11):852.e9-17. DOI: https://doi.org/10.1016/j.jamda.2013.06.010
Lee DM, Tajar A, Ulubaev A, Pendleton N, O’Neill TW, O’Connor DB, Bartfai G. Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. J Neurol Neurosurg Psychiatr. 2009; 80:722–729. DOI: https://doi.org/10.1136/jnnp.2008.165720
Dean AJ, Bellgrove MA, Hall T, Phan WM, Eyles DW, Kvaskoff D, McGrath JJ. Effects of vitamin D supplementation on cognitive and emotional functioning in young adults—a randomised controlled trial. PLoS One. 2011; 6 (11): e25966. DOI: https://doi.org/10.1371/journal.pone.0025966
Belenchia AM, Tosh AK, Hillman LS, Peterson CA. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr. 2013; 97: 774–781. DOI: https://doi.org/10.3945/ajcn.112.050013
Kang JH, Kim SS, Moon SS, Kim WJ, Bae MJ, Choi BG.Adiposity in the Relationship between Serum Vitamin D Level and Insulin Resistance in Middle-Aged and Elderly Korean Adults: The Korea National Health and Nutrition Examination Survey 2008. Endocrinol Metab (Seoul). 2013; 28(2):96-102. DOI: https://doi.org/10.3803/EnM.2013.28.2.96
Kelly A, Brooks LJ, Dougherty S, Carlow DC, Zemel BS. A cross-sectional study of vitamin D and insulin resistance in children. Arch Dis Child. 2011; 96: 447–452. DOI: https://doi.org/10.1136/adc.2010.187591
Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ.National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011; 378:31–40. DOI: https://doi.org/10.1016/S0140-6736(11)60679-X
Joffe A. Correcting Low Vitamin D Levels in Obese Adolescents Improves Insulin Sensitivity. Journal Watch Pediatrics and Adolescent Medicine. Am J Clin Nutr. 2013;39.
Kabadi SM, Lee BK, Liu L. Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006. Diabetes Care. 2012; 35:2048–2054. DOI: https://doi.org/10.2337/dc12-0235
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28: 412–419. DOI: https://doi.org/10.1007/BF00280883
Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, Hewison M. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol. 2004; 89–90:121–125. DOI: https://doi.org/10.1016/j.jsbmb.2004.03.115
Danziger J1, Biggs ML, Niemi M, Ix JH, Kizer JR, Djoussé L. Circulating 25-hydroxyvitamin D is associated with insulin resistance cross-sectionally but not longitudinally in older adults: The Cardiovascular Health Study. Metabolism. 2013; 62(12):1788-94. DOI: https://doi.org/10.1016/j.metabol.2013.07.008
Amini Z1, Bryant S, Smith C, Singh R, Kumar S. Is the serum vitamin D-parathyroid hormone relationship influenced by obesity in children? Horm Res Paediatr. 2013; 80(4):252-6. DOI: https://doi.org/10.1159/000354645
Grethen E, McClintock R, Gupta CE, Jones R, Cacucci BM. Vitamin D and hyperparathyroidism in obesity. J Clin Endocrinol Metab. 2011; 96:1320–1326. DOI: https://doi.org/10.1210/jc.2010-2202
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