Sleep Deficiency is a Modifiable Risk Factor for Obesity and Cognitive Impairment and Associated with Elevated Visfatin


  • Yusr M. I. Kazem Nutrition and Food Sciences Department, National Research Centre, Dokki, Giza, (Affiliation ID: 60014618)
  • Salwa M. El Shebini Nutrition and Food Sciences Department, National Research Centre, Dokki, Giza, (Affiliation ID: 60014618)
  • Maha I. A. Moaty Nutrition and Food Sciences Department, National Research Centre, Dokki, Giza, (Affiliation ID: 60014618)
  • Suzanne Fouad Nutrition and Food Sciences Department, National Research Centre, Dokki, Giza, (Affiliation ID: 60014618)
  • Salwa T. Tapozada Nutrition and Food Sciences Department, National Research Centre, Dokki, Giza, (Affiliation ID: 60014618)



Sleep, cognitive functions, obesity, visfatin, insulin resistance


AIM: To study the interaction between sleep deprivation, obesity and cognitive functions, and the effect of following a balanced low caloric diet and increasing sleep duration on those variables.

SUBJECTS AND METHODS: Ninety two obese females with mean age 47.00 ± 2.00 years and body mass index (BMI) 36.14 ± 3.00 kg/m² were divided into 3 groups according to their sleeping hours. They followed balanced low-caloric diet and were instructed to increase sleeping hours. Full clinical examination, 24 hours dietary intake recall, anthropometric measurements, mini mental state test, questionnaire for subjective sleep and life style evaluation were performed at baseline and after 2 months. Serum visfatin, fasting blood glucose and C-peptide were assessed; Modified homeostatic model assessment of insulin resistance was calculated.

RESULTS: About one third of our sample slept less than 6 hours daily, group (1), all patients had elevated visfatin serum level (33.87 ± 2.8 ng/ml) with the highest level in group (1). At base line, group (1) showed the highest BMI, lowest cognitive functions, highest visfatin level and highest insulin resistance (P < 0.05). After 2 months of intervention, improvement was recorded in all variables, with the best improvement in group (1) after extending sleep duration (P < 0.05).

CONCLUSION: Sleep deprivation may be a modifiable risk factor for obesity, cognitive impairment and visfatin elevation.


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How to Cite

Kazem YMI, El Shebini SM, Moaty MIA, Fouad S, Tapozada ST. Sleep Deficiency is a Modifiable Risk Factor for Obesity and Cognitive Impairment and Associated with Elevated Visfatin. Open Access Maced J Med Sci [Internet]. 2015 Jun. 10 [cited 2021 Jul. 31];3(2):315-21. Available from:



B - Clinical Sciences

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