Glutathione Transferase as a Potential Marker for Gut Epithelial Injury versus the Protective Role of Breast Milk sIgA in Infants with Rota Virus Gastroenteritis

Authors

  • Lobna S. Sherif National Research Centre, Department of Child Health, Giza
  • Randaa K. Abdel Raouf Institute of Postgraduate Childhood Studies - Department of Medical Studies, Cairo
  • Rokaya M. El Sayede Kasralainy Cairo University - Pеdiatric, Cairo
  • Amany S. El Wakkadd National Research Centre, Medical Physiology, Cairo
  • Ashraf R. Shoaib Department of Medical Studies, Institute of Postgraduate Childhood Studies, Ain Shams University, Cairo
  • Hanan M. Ali Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo
  • Amira S. El Refay National Research Centre, Department of Child Health, Giza

DOI:

https://doi.org/10.3889/oamjms.2015.125

Keywords:

viral gastroenteritis, Rota virus, glutathione transferase, secretory IgA, infants

Abstract

BACKGROUND: Secretory immunoglobulin A (SIgA) plays an important protective role in the recognition and clearance of enteric pathogens.

AIM: This study was designed to assess if mucosal integrity “measured by secretory IgA (SIgA)†is a protective factor from more epithelial alteration “measured by glutathione transferase†in infants with Rota gastroenteritis and its relation to infantsꞌ feeding pattern.

PATIENTS AND METHODS: This study was conducted on 79 infants aged 6 months and less from those diagnosed as having gastroenteritis and admitted to Gastroenteritis Department in Abo El Rish Pediatric Hospital, Cairo University. Plasma glutathione s-transferases and Stool SIgA were measured using ELISA technique. Rota virus detection was done by Reverse transcriptase PCR.

RESULTS: SIgA was found to be significantly positive in exclusive breast fed infants, Glutathione transferase was significantly more frequently positive in Rota positive cases than Rota negative cases by Reverse transcriptase PCR. A significant negative correlation between Glutathione transferase and Secretory IgA was found, (p < 0.05).

CONCLUSION: Breast feeding should be encouraged and highly recommended in the first two years of life as it provides Secretory IgA to breast fed infants who in turn protect them against epithelial damage caused by Rota viral gastroenteritis.

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Published

2015-11-26

How to Cite

1.
Sherif LS, Abdel Raouf RK, El Sayede RM, El Wakkadd AS, Shoaib AR, Ali HM, El Refay AS. Glutathione Transferase as a Potential Marker for Gut Epithelial Injury versus the Protective Role of Breast Milk sIgA in Infants with Rota Virus Gastroenteritis. Open Access Maced J Med Sci [Internet]. 2015 Nov. 26 [cited 2022 Aug. 15];3(4):676-80. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2015.125

Issue

Section

B - Clinical Sciences

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