Association between Increased Matrix Metalloproteinase-9 (MMP-9) Levels with Hyperglycaemia Incidence in Acute Ischemic Stroke Patients

Authors

  • Ismail Setyopranoto Department of Neurology, Faculty of Medicine, Universitas Gadjah Mada and Dr Sardjito General Hospital, Yogyakarta, Indonesia https://orcid.org/0000-0003-4768-7113
  • Rusdy Ghazali Malueka Department of Neurology, Faculty of Medicine, Universitas Gadjah Mada and Dr Sardjito General Hospital, Yogyakarta, Indonesia https://orcid.org/0000-0001-6835-0638
  • Andre Stefanus Panggabean Department of Neurology, Faculty of Medicine, Universitas Gadjah Mada and Dr Sardjito General Hospital, Yogyakarta, Indonesia https://orcid.org/0000-0002-0459-3339
  • I Putu Eka Widyadharma Department of Neurology, Faculty of Medicine, Udayana University and Sanglah General Hospital, Bali, Indonesia https://orcid.org/0000-0002-4554-0348
  • Ahmad Hamim Sadewa Department of Biochemistry, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia https://orcid.org/0000-0002-3514-6646
  • Rusdi Lamsudin Department of Neurology, Faculty of Medicine, Universitas Gadjah Mada and Dr Sardjito General Hospital, Yogyakarta, Indonesia
  • Samekto Wibowo Department of Neurology, Faculty of Medicine, Universitas Gadjah Mada and Dr Sardjito General Hospital, Yogyakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2018.459

Keywords:

Hyperglycemia, Matrix metalloproteinase-9 (MMP-9), Acute ischemic stroke

Abstract

BACKGROUND: Hyperglycemia is common in acute stroke patients. Hyperglycemia can induce the production of reactive oxygen species, causing increased activity of matrix metalloproteinase-9 (MMP-9).

AIM: This study aimed to determine an association between the increased levels of MMP-9 and the incidence of hyperglycemia in acute ischemic stroke patients.

METHODS: This is a case-control study. Acute ischemic stroke patients admitted to the Stroke Unit of a reference hospital in Yogyakarta, Indonesia was divided into the hyperglycemic and non-hyperglycemic group. Demographic and clinical characteristics of each subject were recorded, and blood levels of MMP-9 were measured. Seventy-one patients were recruited, 40 subjects in the hyperglycemic group and 31 subjects in the non-hyperglycemic group.

RESULTS: The median levels of blood MMP-9 level in the hyperglycemic and non-hyperglycemic group were 974.37 and 748.48 ng/mL, respectively, and the difference was statistically not significant (95% CI, 191.24-2849.53; p = 0.07). When the calculated cut-off point of 600.99 ng/mL was used, the proportion of patients with higher MMP-9 levels was significantly more in the hyperglycemic group compared with the ones in the non-hyperglycemic group (82.5% and 54.8%, respectively; OR = 3.88; p = 0.011).

CONCLUSION: We concluded that the proportion of patients with MMP-9 level >600.99 ng/mL was significantly higher in acute ischemic stroke patients with hyperglycemia.ng/mL was significantly higher in acute ischemic stroke patients with hyperglycemia.

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Published

2018-11-18

How to Cite

1.
Setyopranoto I, Malueka RG, Panggabean AS, Widyadharma IPE, Sadewa AH, Lamsudin R, Wibowo S. Association between Increased Matrix Metalloproteinase-9 (MMP-9) Levels with Hyperglycaemia Incidence in Acute Ischemic Stroke Patients. Open Access Maced J Med Sci [Internet]. 2018 Nov. 18 [cited 2022 May 17];6(11):2067-72. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.459

Issue

Section

B - Clinical Sciences

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