Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) Modulates TCD4+ and TCD8+ Cell Profile of Doxorubicin-Induced Immuno-Suppressed Rats

Authors

  • Mustafa Ridwan Lubis Pharmacy Academy of Indah Medan, Medan, Indonesia
  • Reny Haryani Pharmacy Academy of Indah Medan, Medan, Indonesia
  • Safriana Safriana Pharmacy Academy of Indah Medan, Medan, Indonesia
  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.501

Keywords:

Picria fel-terrae Lour., Ethanolic Extract, doxorubicin, immunomodulator, TCD4, TCD8

Abstract

AIM: To evaluate the immunomodulatory effects of ethanolic extract of herb pugun tanoh on TCD4 and TCD8 cells in Doxorubicin-induced rats.

METHODS: Fifteen male Sprague Dawley rats were divided into five groups consisting of six rats each as follows: Group 1, DOX-treated rats (4.67 mg/kg BW body weight on day 1 and 4) and were administered normal saline 0.9% orally once daily for 7 consecutive days, Group 2, receiving Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) of dose 150 mg/kg BW orally, Group 3, receiving dose Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) 300 mg/kg BW orally. The rats of group 2-3 were intramuscularly administered with doxorubicin at a dose of 4.67 mg/kg BW at the days 1-4 to suppress immune functions.

RESULTS: Treatment of 300 mg/kg BW of Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) succeeded in reducing side effect doxorubicin based on increasing the TCD4+ and TCD8+ blood level.

CONCLUSION: Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) could increase the level of TCD4+ and TCD8+ in rats which induced by doxorubicin.

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Published

2019-11-14

How to Cite

1.
Lubis MR, Haryani R, Safriana S, Satria D. Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) Modulates TCD4+ and TCD8+ Cell Profile of Doxorubicin-Induced Immuno-Suppressed Rats. Open Access Maced J Med Sci [Internet]. 2019 Nov. 14 [cited 2024 Jun. 17];7(22):3774-6. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.501

Issue

Section

Herbal Medicine in Pharmaceutical and Clinical Sciences

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