The PI3KCA and AKT Inhibitory Activities of Litsea Cubeba Lour. Fruits and Heartwoods Towards Hela Cells
Keywords:Litsea cubeba Lour, Fruits, Heartwoods, PI3KCA, Akt
AIM: To investigated the activities of chloroform fractions at pH 7 of Litsea cubeba Lour. Fruits and heartwoods (CF-7F and CF-7H) in decrease expression of PI3KCA, Akt-1 and Akt-2 genes towards cervical cancer cell culture (HeLa) experiments in vitro.
MATERIAL AND METHODS: CF-7F and CF-7H (12.5 and 25 Âµg/mL) were tested for its potential inhibition on gene expression of PI3KCA, Akt-1 and Akt-2 genes by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) method.
RESULT: CF-7F and CF-7H were showed the activity to reduce the expression of PI3KCA, Akt-1 and Akt-2 genes.
CONCLUSION: Our results suggest that CF-7F and CF-7H significantly inhibit the expression of PI3KCA, Akt-1 and Akt-2 genes.
Plum Analytics Artifact Widget Block
How to Cite
Copyright (c) 2019 Aminah Dalimunthe, Poppy Anjelisa Zaitun Hasibuan, Denny Satria
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.