Correlation between Vitamin D and Uric Acid in Menopausal Women

Authors

  • Arvitamuriany Lubis Department of Obstetric and Gynecologic, Medical Faculty, University of North Sumatra, General Hospital Haji Adam Malik Medan, Sumatera Utara, Indonesia
  • Muhammad Fidel Ganis Siregar Department of Obstetric and Gynecologic, Medical Faculty, University of North Sumatra, General Hospital Haji Adam Malik Medan, Sumatera Utara, Indonesia
  • Mohammad Iman Syahputra Department of Obstetric and Gynecologic, Medical Faculty, University of North Sumatra, General Hospital Haji Adam Malik Medan, Sumatera Utara, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.10179

Keywords:

Menopause, Vitamin D, Uric acid

Abstract

Background : Vitamin D deficiency and hyperuricemia are global health problems in post-menopausal women in which parathyroid hormone increases hyperuricemia incidence.

Aim : This research purpose to  determine correlation between vitamin D and uric acid levels in postmenopausal women

Methods: This research is an observational analytic study with a cross-sectional study design conducted at University of North Sumatra Hospital and Network Hospital in Medan for 12 months on 40 postmenopausal women who met inclusion and exclusion criteria. The data will be analyzed descriptively to determine variables frequency distribution. Previously, normality test of numerical data is carried out. If the data is normally distributed, Pearson correlation test will be carried out, and if the data is not normally distributed, then Spearman correlation test will be used.

Results : Mean vitamin D of the sample was 23.11 ng/mL with a standard deviation 4.43 and median value 23.5 ng/mL. while the mean uric acid was 7.52 mg/dL with a standard deviation 0.92 and median value 7.45 mg/dL. There is an inverse relationship between uric acid levels and Vitamin D, as evidenced by Pearson test correlation coefficient of -0.541 with p value = 0.001.

Conclusion : There is an inverse correlation between Vitamin D and uric acid levels.

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References

Rees M. Menopause for the MRCOG and Beyond. London: RCOG; 2009. DOI: https://doi.org/10.1017/CBO9781139696937

Chen Y, Cheng J, Chen Y, Wang N, Xia F, Chen C, et al. Association between serum Vitamin D and uric acid in the Eastern Chinese population: A population-based cross-sectional study. BMC Endocr Disord. 2020;20(1):79. https://doi.org/10.1186/s12902-020-00560-1 PMid:32493273 DOI: https://doi.org/10.1186/s12902-020-00560-1

Ioannou G, Boyko E. Effects of menopause and hormone replacement therapy on the associations of hyperuricemia with mortality. Atherosclerosis. 2013;226(1):220-7. https://doi.org/10.1016/j.atherosclerosis.2012.10.044 PMid:23141471 DOI: https://doi.org/10.1016/j.atherosclerosis.2012.10.044

Pérez-López F, Chedraui P, Pilz S. Vitamin D supplementation after the menopause. Ther Adv Endocrinol Metab. 2020;11:2042018820931291. https://doi.org/10.1177/2042018820931291 PMid:32551035 DOI: https://doi.org/10.1177/2042018820931291

Peng H, Li H, Li C, Chao X, Zhang Q, Zhang Y. Association between Vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese Han women. PLoS One. 2013;8(4):e61159. https://doi.org/10.1371/journal.pone.0061159 PMid:23585876 DOI: https://doi.org/10.1371/journal.pone.0061159

Thakkinstian A, Anothaisintawee T, Chailurkit L, Ratanachaiwong W, Yamwong S, Sritara P, et al. Potential causal associations between Vitamin D and uric acid: Bidirectional mediation analysis. Sci Rep. 2015;5(1):14528. https://doi.org/10.1038/srep14528 PMid:26417870 DOI: https://doi.org/10.1038/srep14528

Hansen KE, Johnson E, Chambers KR, Johnson MG, Lemon CC, Vo TN, et al. Treatment of Vitamin D insufficiency in postmenopausal women a randomized clinical trial. JAMA Intern Med. 2015;175(10):1612-21. https://doi.org/10.1001/jamainternmed.2015.3874 PMid:26237520 DOI: https://doi.org/10.1001/jamainternmed.2015.3874

Kang S, Kwon D, Lee J, Chung YJ, Kim MR, Namkung J, et al. Association between serum uric acid levels and bone mineral density in postmenopausal women: A cross-sectional and longitudinal study. Healthcare (Basel). 2021;9(12):1681. https://doi.org/10.3390/healthcare9121681 PMid:34946407 DOI: https://doi.org/10.3390/healthcare9121681

Charoenngam N, Ponvilawan B, Ungprasert P. Vitamin D insufficiency and deficiency are associated with a higher level of serum uric acid: A systematic review and meta-analysis. Mod Rheumatol. 2020;30(2):385-90. https://doi.org/10.1080/143975 95.2019.1575000 PMid:30689484 DOI: https://doi.org/10.1080/14397595.2019.1575000

Nimitphong H, Saetung S, Chailurkit L, Chanprasertyothin S, Ongphiphadhanakul B. Vitamin D supplementation is associated with serum uric acid concentration in patients with prediabetes and hyperuricemia. J Clin Transl Endocrinol. 2021;24:100255. https://doi.org/10.1016/j.jcte.2021.100255 PMid:33898272 DOI: https://doi.org/10.1016/j.jcte.2021.100255

Isnuwardana R, Bijukchhe S, Thadanipon K, Ingsathit A, Thakkinstian A. Association between Vitamin D and uric acid in adults: A systematic review and meta-analysis. Horm Metab Res. 2020;52(10):732-41. https://doi.org/10.1055/a-1240-5850 PMid:33049785 DOI: https://doi.org/10.1055/a-1240-5850

Takır M, Solak Y, Erek A, Köstek O, Oral A, Elçioğlu Ö, et al. Association between elevated serum uric acid and Vitamin D insufficiency among the middle-aged and elderly population. Turk Nephrol Dial Transplant. 2016;25(2):182-6. DOI: https://doi.org/10.5262/tndt.2016.1002.10

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Published

2022-08-18

How to Cite

1.
Lubis A, Siregar MFG, Syahputra MI. Correlation between Vitamin D and Uric Acid in Menopausal Women. Open Access Maced J Med Sci [Internet]. 2022 Aug. 18 [cited 2024 Mar. 29];10(B):1936-9. Available from: https://oamjms.eu/index.php/mjms/article/view/10179

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Gynecology and Obstetrics

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