Indicators of Moderate and Severe Preeclampsia in Correlation with Maternal IL10
DOI:
https://doi.org/10.3889/oamjms.2016.047Keywords:
Indicators, preeclampsia, IL10, logistic regressionAbstract
AIM: The purpose of the actual study was to evaluate the relationship between the formation of anti-inflammatory cytokine IL10 and several indicators of moderate and severe preeclampsia in the third trimester of pregnancy.
MATERIAL AND METHODS: Examination of the indicators of preeclampsia and maternal IL10 levels was conducted in 50 women with pregnancies complicated by varying degrees of preeclampsia in the third trimester of gestation as well as in 50 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. The levels of IL10 were determined with a commercial test developed by Orgenium Laboratories (Finland), using reagents from AviBion ELISA research kits. Patients with preeclampsia were categorized into moderate and severe preeclampsia group according to the degree of preeclampsia. Logistic regression analysis was used to determine the predictive value of different parameters for the occurrence of severe preeclampsia. Odds ratios and 95% Confidence Intervals were calculated in order to quantify independent associations.
RESULTS: The regression analysis detected systolic blood pressure (160 mmHg or higher), diastolic blood pressure (100 mmHg or higher), persistent proteinuria in pregnancy, serum LDH concentration (450 U/L or higher) and reduced serum concentrations of IL10 as significant predictors of severe preeclampsia in pregnant women after adjusting for age.
CONCLUSION: The findings of significantly lower serum IL10 concentrations in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe preeclampsia.Downloads
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Vikhlyaeva M. Preclinical manifestations of systemic disorders, clinical outcomes and long-term effects of preeclampsia. Obstetrics and Gynecology. 2009; 1: 3-6.
Tsatsaris V, Fournier T, Winer N. Patho- physiology of preeclampsia. European Journal of Obste- trics & Gynecology and Reproductive Biology. 2008; 1: 16-23.
http://dx.doi.org/10.1016/j.jgyn.2007.08.003
PMid:18036745
Sukhih G.T, Vanko L.V. Immune factors in the etiology and pathogenesis of pregnancy complications. Obstetrics and Gynecology. 2012; 1: 128-136.
Lewis D.F, Canzoneri B.J, Wang Y. Maternal circulating TNF-alpha levels are highly correlated with IL-10 levels, but not IL-6 and IL-8 levels, in women with pre-eclampsia. American Journal Reproductive Immunology. 2009; 5: 269-274.
http://dx.doi.org/10.1111/j.1600-0897.2009.00735.x
PMid:19706021 PMCid:PMC3062435
Kalkunte S, Nevers T, Norris W.E, Sharma S. Vascular IL-10. A protective role in preeclampsia. Journal of Reproductive Immunology. 2011; 88: 165-169.
http://dx.doi.org/10.1016/j.jri.2011.01.009
PMid:21334073 PMCid:PMC3621108
Tosun M, Celik H, Avci B, Yavuz E, Alper T, MalatyalioÄŸlu E. Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by Preeclampsia. Journal of Maternal-Fetal and Neonatal Medicine. 2010; 23: 880-886.
http://dx.doi.org/10.3109/14767051003774942
PMid:20441409
Molvarec A, Szarka A, Walentin S, Beko G, Karádi I, Prohászka Z. Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia. Reproductive Biology and Endocrinology. 2011; 9: 124-133.
http://dx.doi.org/10.1186/1477-7827-9-124
PMid:21906313 PMCid:PMC3184629
Bosio PM, McKenna PJ, Conroy R, O'Herlihy C. Maternal central hemodynamics in hypertensive disorders of pregnancy. Obstet Gynecollogy.1999; 94: 978– 984.
http://dx.doi.org/10.1097/00006250-199912000-00014
Lim KH, Friedman SA, Ecker JL, Kao L, Kilpatrick SJ. The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. Am J Obstet Gynecol. 1998;178:1067–71.
http://dx.doi.org/10.1016/S0002-9378(98)70549-6
Makarov IO, Shemanaeva TV, Hasanov SR, Popova OP. Preeclampsia as a manifestation of immune endotheliosis. The Questions of Gynecology Obstetrics and Perinatology. 2009; 6: 17-22.
Sidorova IS, Gurin OI, Milovanov AP. The pathogenesis of preeclampsia as a manifestation of immune-endothelial pathology (acute immune endothe- liosis). Obstetrics and Gynecology. 2008; 6: 13-17.
Hashii K, Fujiwara S, Yoshioka N, Kataoka S, Yamada T, Hirano T. Peripheral blood mononuclear cells stimulate progesterone production by luteal cells derived from pregnant and nonpregnant women: possible involvement of interleukin-4 and interleukin-10 in corpus luteum function and differentiation. Human Reprod. 1998; 13:2738.
http://dx.doi.org/10.1093/humrep/13.10.2738
Chaouat G, Meliani J, Martal R. IL-10 prevents naturally occurring fetal loss in the CBA 3 DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-t. J Immunol. 1995; 154: 4261.
PMid:7722286
Delassus S, Coutinho C, Saucier S, Darche, Kourilsky P. Differential cytokine expression in maternal blood and placenta during murinegestation. J Immunol. 1994; 152: 2411.
PMid:8133052
Athanassakis I, Iconomidou B. Cytokine production in the serum and spleen of mice from day 6 to 14 of gestation: cytokines/placenta/spleen/serum. Dev Immunol. 1996; 4:247.
http://dx.doi.org/10.1155/1995/42412
PMid:8924760 PMCid:PMC2275966
Piccinni MP, Giudizi G, Biagotti R, Beloni L, Giannarini L. Progesterone favors the development of human T helper cells producing Th2 type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol. 1995; 155:128.
PMid:7541410
Rijhsinghani AG, Thompson K, Tygrette, Bhatia S. K. Inhibition of interleukin-10 during pregnancy results in neonatal growth retardation. Am J Reprod Immunol. 1997; 37: 232.
http://dx.doi.org/10.1111/j.1600-0897.1997.tb00220.x
PMid:9127644
Côté AM, Firoz T, Mattman A. The 24-hour urine collection: gold standard or historical practice. Am J Obstet Gynecol. 2008; 199:625.
http://dx.doi.org/10.1016/j.ajog.2008.06.009
PMid:18718568
Chen BA, Parviainen K, Jeyabalan A. Correlation of catheterized and clean catch urine protein/creatinine ratios in preeclampsia evaluation. Obstet Gynecol. 2008; 112:606.
http://dx.doi.org/10.1097/AOG.0b013e3181827c89
PMid:18757659
Khazardoost S, Abdollahi A, Shafaat M. Comparison of 8-h urine protein and random urinary protein-to-creatinine ratio with 24-h urine protein in pregnancy. J Matern Fetal Neonatal Med. 2012; 25:138.
http://dx.doi.org/10.3109/14767058.2011.564243
PMid:21689049
McCrae KR .Thrombocytopenia in Pregnancy in Platelets. 2006; 925–933.
Etienne C, James J. W. Pre-eclampsia, Severe Pre-eclampsia and Hemolysis, Elevated Liver Enzymes and Low Platelets Syndrome. Women's Health. 2011;7: 555-569.
http://dx.doi.org/10.2217/whe.11.57
PMid:21879824
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