Association between Glycated Hemoglobin with the Levels of Serum Proinflammatory Cytokines and Antioxidants in Patients with Type 2 Diabetes Mellitus in Universitas Sumatera Utara Hospital

Authors

  • Mutiara Indah Sari Departement of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr Mansur No.5 Medan, Indonesia
  • Zaimah Z. Tala Departement of Clinical Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr Mansur No.5 Medan, Indonesia
  • Dian Dwi Wahyuni Departement of Microbiology, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr Mansur No.5 Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.168

Keywords:

Glycated Hemoglobin, Interleukin-6, Glutathione peroxidase, Glutathione, T2DM

Abstract

BACKGROUND: Hyperglycemia condition in diabetes mellitus (DM) influences proinflammatory cytokine levels and disrupts antioxidant balances. Glycated Hemoglobin is used as a biomarker of glycemic control in DM.

AIM: This study aimed to analyse the association between glycated Hemoglobin with the levels of serum proinflammatory cytokines (interleukin (IL)-6) and antioxidants (glutathione peroxidase (GPx) and glutathione (GSH)) in type 2 diabetes mellitus (T2DM) patients in Universitas Sumatera Utara (USU) Hospital.

METHODS: A total of eighty-nine T2DM patients were recruited at USU Hospital. Glycated Hemoglobin levels were measured using routine laboratory tests at USU Hospital. The IL-6, GPx, and GSH levels were measured using enzyme-linked immunosorbent (ELISA) method. The statistical significance was determined using the Kruskal Wallis test, followed by Mann-Whitney test (p < 0.05).

RESULTS: The mean of glycated hemoglobin (%), IL-6 (pg/ml), GPx (ng/ml), and GSH (ng/ml) levels in T2DM patients were 8.96 ± 2.28, 59.27 ± 16.04, 32.13 ± 12.10, and 7.42 ± 3.50, respectively. Regarding the glycated Hemoglobin levels, 28.09% of patients had controlled diabetes, 24.72% of patients had poorly controlled diabetes, and 47.19% of patients had uncontrolled diabetes. The IL-6 levels of the three study groups based on glycated Hemoglobin levels were related significantly (p < 0.05), but there was no statistically significant difference observed between the GPx and GSH levels (p > 0.05).

CONCLUSION: The present study suggests that the glycated Hemoglobin was associated with the levels of serum IL-6 levels but not GPx and GSH levels in T2DM patients in USU Hospital.

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Published

2019-03-10

How to Cite

1.
Sari MI, Tala ZZ, Wahyuni DD. Association between Glycated Hemoglobin with the Levels of Serum Proinflammatory Cytokines and Antioxidants in Patients with Type 2 Diabetes Mellitus in Universitas Sumatera Utara Hospital. Open Access Maced J Med Sci [Internet]. 2019 Mar. 10 [cited 2024 Apr. 21];7(5):715-20. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.168

Issue

Section

A - Basic Science

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