Utilisation of Cryolipolysis among Asians: A Review on Efficacy and Safety

Imam Budi Putra; Nelva Karmila Jusuf; Nani Kumala Dewi

doi:10.3889/oamjms.2019.318

Authors

Imam Budi Putra Department of Dermatology and Venereology, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia
Nelva Karmila Jusuf Department of Dermatology and Venereology, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia
Nani Kumala Dewi Department of Dermatology and Venereology, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.318

Keywords:

Cryolipolysis, Efficacy, Safety, Asian

Abstract

Cryolipolysis is a non-invasive fat reduction method that is capable of reducing subcutaneous fat significantly without damaging surrounding tissues, by applying cold temperature to induce adipocyte apoptosis. Most of the clinical studies in cryolipolysis were conducted in the Caucasian population, and only a few numbers in Asian, who has darker skin with Fitzpatrick skin type III to V. Higher rate of pigmentary changes were reported with the use of cryotherapy in darker skin. Therefore, this report is aimed to provide a comprehensive review regarding utilisation, efficacy and safety profiles of cryolipolysis among Asians. Currently, there are only four clinical trials conducted exclusively in an Asian population. Two studies were conducted in Korea, whereas others in China and Thailand. Cryolipolysis was performed in the abdomen, arm, inner thighs, and submental regions. The reported side effects were mild and transient, including erythema, hematoma, numbness, and pain. There were no pigmentary changes reported. Although only limited data available, those studies have proved that cryolipolysis utilisation among Asians or darker skin types provides the same efficacy and safety profiles as in Caucasians. Therefore, cryolipolysis might be proposed as the first treatment choice for Asian patients who opted to do body contouring.

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References

Ho D, Jagdeo J. A Systematic Review of Paradoxical Adipose Hyperplasia (PAH) Post-Cryolipolysis. J D Drugs Dermatol. 2017; 16(1)62-67.

American Society for Dermatologic Surgery. ASDS Consumer Review on Cosmetic Dermatologic Procedures, 2018.

American Society for Aesthetic Plastic Surgery. Cosmetic surgery national data bank statistics, 2014.

Chang SL, Huang YL, Lee MC, Chang CH, Lin YF, Cheng CY, Hu S. Long-term follow-up for noninvasive body contouring treatment in Asians. Lasers Med Sci. 2016; 31:283-287. https://doi.org/10.1007/s10103-015-1852-0 PMid:26714982

Kennedy J, Verne S, Griffith R, Falto-Aizpurua L, Nouri K. Non-invasive subcutaneous fat reduction: a review. J Eur Acad Dermatol Venereol. 2015; 29(9):1679-88. https://doi.org/10.1111/jdv.12994 PMid:25664493

Macedo O, Corradini C, Matayoshi L. Cryolipolysis treatment for subcutaneous fat layer reduction. J Am Acad Dermatol. 2012; 66(4)(Supp1):AB25. https://doi.org/10.1016/j.jaad.2011.11.113

Derrick CD, Shridarani Sm, Broyles JM. The safety and efficacy of cryolipolysis: A systematic review of available literature. Aesthet Surg J. 2015; 35(7):830-836. https://doi.org/10.1093/asj/sjv039 PMid:26038367

Chan IL, Cohen S, da Cunha MG, Maluf LC. Characteristics and management of Asian skin. Int J Dermatol. 2018 2019; 58(2):131-143. https://doi.org/10.1111/ijd.14153 PMid:30039861

Korpan NN. A history of cryosurgery: its development and future. J Am Coll Surg. 2007; 204(2):314-324. https://doi.org/10.1016/j.jamcollsurg.2006.11.006 PMid:17254936

Jalian H, Avram MM. Cryolipolysis: a historical perspective and current clinical practice. Semin Cutan Med Surg. 2013; 32(1):31-4.

Haxthausen H. Adiponecrosis E Frigore. British J Dermatol. 1941; 53(3):83-9. https://doi.org/10.1111/j.1365-2133.1941.tb10506.x

Avram MM, Harry RS. Cryolipolysisâ„¢ for subcutaneous fat layer reduction. Laser surg med. 2009; 41(10):703-8. https://doi.org/10.1002/lsm.20864 PMid:20014262

Beacham BE, Cooper PH, Buchanan CS, Weary PE. Equestrian cold panniculitis in women. Arch Dermatol. 1980; 116(9):1025-7. https://doi.org/10.1001/archderm.1980.01640330063014 PMid:7191239

Epstein EH Jr, Oren ME. Popsicle panniculitis. N Engl J Med. 1970; 82:966-967. https://doi.org/10.1056/NEJM197004232821709 PMid:5436034

Ingargiola MJ, Motakef S, Chung MT, Vasconez HC, Sasaki GH. Cryolipolysis for fat reduction and body contouring: Safety and efficacy of current treatment paradigms. Plast Reconstr Surg. 2015; 135:1581-90. https://doi.org/10.1097/PRS.0000000000001236 PMid:26017594 PMCid:PMC4444424

Manstein D, Laubach H, Watanabe K, Farinelli W, Zurakowski D, Anderson RR. Selective cryolysis: A novel method of noninvasive fat removal. Lasers Surg Med. 2008; 40:595-604. https://doi.org/10.1002/lsm.20719 PMid:18951424

Zelickson B, Egbert BM, Preciado J, Allison J, Springer K, Rhoades RW, et al. Cryolipolysis for noninvasive fat cell destruction: initial results from a pig model. Dermatol Surg. 2009; 35(10):1462-70. https://doi.org/10.1111/j.1524-4725.2009.01259.x PMid:19614940

Kilmer SL. Prototype CoolCup cryolipolysis applicator with over 40% reduced treatment time demonstrates equivalent safety and efficacy with greater patient preference. Lasers Surg Med. 2017; 49(1):63-68. https://doi.org/10.1002/lsm.22550 PMid:27327898 PMCid:PMC5298010

Bolton J, Wu D, Goldman M. Study of a suctionless novel applicator for the treatment of pseudogynecomastia with cryolipolysis. Lasers Surg Med. 2016; 48(4):451.

Shek SY, Chan NP, Chan HH. Non-invasive cryolipolysis for body contouring in Chinese: A first commercial experience. Lasers Surg Med. 2012; 44:125-130. https://doi.org/10.1002/lsm.21145 PMid:22334296

Lee KR. Clinical efficacy of fat reduction on the thigh of Korean women through cryolipolysis. J Obes Weight Loss. 2013; 3:1-5. https://doi.org/10.4172/2165-7904.1000203

Wanitphakdeedcha R, Sathaworawong A, Manuskiatti W. The efficacy of cryolipolysis treatment on arms and inner thighs. Lasers Med Sci. 2015; 30:2165-2169. https://doi.org/10.1007/s10103-015-1781-y PMid:26100004 PMCid:PMC4598345

Suh DH, Park JH, Jung HK, Lee SJ, Kim HJ, Ryu HJ. Cryolipolysis for submental fat reduction in Asians. Journal of Cosmetic and Laser Therapy. 2018; 20(1):24-27. https://doi.org/10.1080/14764172.2017.1368564 PMid:28850270

Krueger N, Mai SV, Luebberding S, Sadick NS. Cryolipolysis for noninvasive body contouring: clinical efficacy and patient satisfaction. Clinical, Cosmetic and Investigational Dermatology. 2014; (7):201-205. https://doi.org/10.2147/CCID.S44371 PMid:25061326 PMCid:PMC4079633

Dover JA, Burns J, Coleman S, Fitzpatrick R, Garden J, Goldberg D. A prospective clinical study of noninvasive cryolipolysis for subcutaneous fat layer reduction-interim report of available subject data Lasers in surgery and medicine. Hoboken: John wiley and Sons; 2009.

Coleman SR, Sachdeva K, Egbert BM, Preciado J, Allison J. Clinical efficacy of noninvasive cryolipolysis and its effects on peripheral nerves. Aesthetic Plast Surg. 2009; 33(4):482-448. https://doi.org/10.1007/s00266-008-9286-8 PMid:19296153

Dierickx CC, Mazer JM, Sand M, Koenig S, Arigon V. Safety, tolerance, and patient satisfaction with noninvasive cryolipolysis. Dermatol Surg. 2013; 39(8):1209-1216. https://doi.org/10.1111/dsu.12238 PMid:23639062

Garibyan L, Sipprell WH, Jalian HR, Sakamoto FH, Avram M, Anderson RR. Three-dimensional volumetric quantification of fat loss following cryolipolysis. Lasers Surg Med. 2014; 46(2):75-80. https://doi.org/10.1002/lsm.22207 PMid:24535759 PMCid:PMC4123113

Ferraro GA, De Francesco F, Cataldo C, Rossano F, Nicoletti G, D'Andrea F. Synergistic effects of cryolipolysis and shock waves for noninvasive body contouring. Aesthetic Plast Surg. 2012; 36(3):666-679. https://doi.org/10.1007/s00266-011-9832-7 PMid:22042359

Bernstein EF. Longitudinal evaluation of cryolipolysis efficacy: two case studies. J Cosmet Dermatol. 2013; 12(2):149-152. https://doi.org/10.1111/jocd.12036 PMid:23725309

Carruthers J, Stevens WG, Carruthers A, Humphrey S. Cryolipolysis and skin tightening. Dermatol Surg. 2014; 40:S184-9. https://doi.org/10.1097/DSS.0000000000000229 PMid:25417573

Bernstein EF, Bloom JD. Safety and efficacy of bilateral submental cryolipolysis with quantified 3-dimensional imaging of fat reduction and skin tightening. JAMA Facial Plast Surg. 2017; 19(5):350-357. https://doi.org/10.1001/jamafacial.2017.0102 PMid:28426847 PMCid:PMC5815121

Munavalli GS, Panchaprateep R. Cryolipolysis for targeted fat reduction and improved appearance of the enlarged male breast. Dermatol Surg. 2015; 41:1043-1051. https://doi.org/10.1097/DSS.0000000000000415 PMid:26218826

Sasaki GH, Abelev N, Tevez-Ortiz A. Noninvasive selective cryolipolysis and reperfusion recovery for localized natural fat reduction and contouring. Aesthet Surg J. 2014; 34:420-431. https://doi.org/10.1177/1090820X13520320 PMid:24598865

Boey GE, Wasilenchuk JL. Enhanced clinical outcome with manual massage following cryolipolysis treatment: A 4-month study of safety and efficacy. Lasers Surg Med. 2014; 46:20-26. https://doi.org/10.1002/lsm.22209 PMid:24338439 PMCid:PMC4265298

Jalian HR, Avram MM, Garibyan L, Mihm MC, Anderson RR. Paradoxical adipose hyperplasia after cryolipolysis. JAMA Dermatol. 2014; 150(3):317-319. https://doi.org/10.1001/jamadermatol.2013.8071 PMid:24382640 PMCid:PMC4171727

Stevens WG, Pietrzak LK, Spring MA. Broad overview of a clinical and commercial experience with CoolSculpting. Aesthetic Surg J. 2013; 33(6):835-846. https://doi.org/10.1177/1090820X13494757 PMid:23858510

Klein KB, Zelickson B, Riopelle JG, et al. Non-invasive cryolipolysis for subcutaneous fat reduction does not affect serum lipid levels or liver function tests. Lasers Surg Med. 2009; 41(10):785-790. https://doi.org/10.1002/lsm.20850 PMid:20014252

Riopelle JT, Kovach B. Lipid and liver function effects of thecryolipolysis procedure in a study of male love handle reduction. Lasers Surg Med. 2009:82.

Pinto H, Arredondo E, Ricart-Jane D. Evaluation of adipocyticchanges after a simil-lipocryolysis stimulus. Cryo Letters. 2013; 34:100-105.