Preparation of In Situ Cross-Linked N-Maleoyl Chitosan-Oxidized Sodium Alginate Hydrogels for Drug Delivery Applications

Subur P. Pasaribu; Jamaran Kaban; Mimpin Ginting; Jansen Silalahi

doi:10.3889/oamjms.2019.850

Authors

Subur P. Pasaribu Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan-20155, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda-75123, Indonesia
Jamaran Kaban Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan-20155, Indonesia
Mimpin Ginting Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan-20155, Indonesia
Jansen Silalahi Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan-20155, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.850

Keywords:

In situ, Schiff base, MCS-OSA hydrogels, Physicochemical, Drug delivery

Abstract

AIM: This study was aimed to prepare in situ cross-linked N-maleoyl chitosan â€“ oxidised sodium alginate (MCS â€“ OSA) hydrogel loaded with metronidazole (MTZ) for drug delivery applications.

METHODS: The hydrogel was prepared by in situ cross-linking via Schiff base reaction between amine (-NH2) groups from MCS and aldehyde (-CHO) groups from OSA at the different ratio, and the MTZ was loaded into the hydrogels along with the gelatin processes.

RESULTS: The highest drug entrapment efficiency (DEE) was exhibited by MTZ-H3 (5: 5) with DEE of 99.20% and a gel fraction of 97.52%. FTIR results revealed that Schiff base reaction was occurred by the absorption peak of â€“C = N- groups at 1628 cm^-1 and indicated that there is insignificant alteration at different ratio of MCS and OSA. The best sustained of in vitro release profiles of MTZ was shown by MTZ-H3, which is 74.92% and 75.65% at pH 1.2 and 7.4 for 12 h of release, respectively.

CONCLUSION: The optimised ratio between MCS and OSA to prepare in situ cross-linked hydrogels were found to be 5:5 according to the results of DEE and in vitro drug release profiles of MTZ and the MTZ loaded MCS-OSA hydrogels have a great potential which can be applied in biomedical applications.