Correlation of Coagulation Parameters with Clinical Outcome of Critically Ill Patients with COVID-19 Admitted to an Intensive Care at Rsup Dr. M. Djamil in Indonesia
DOI:
https://doi.org/10.3889/oamjms.2022.9037Keywords:
COVID-19, Critically ill, Coagulation, INR, D-dimer, Platelet, Days 5Abstract
BACKGROUND: COVID-19 is a condition that is characterized by an abnormal coagulation state, which is a reason for severe thrombotic problems.
AIM: We aim to determine the correlation of coagulation parameters levels with clinical outcomes of critically ill patients with COVID-19 admitted to intensive care at a national referral hospital in Indonesia.
METHODS: This retrospective cohort study analyzed 227 patients with a primary diagnosis of COVID-19 on mechanical ventilation who were admitted to the COVID-19 intensive care unit, Dr. M. Djamil from 2020 to 2021 taken in the medical record. Numerical data were analyzed using an independent t-test, while the categorical data were analyzed using the Chi-square test.
RESULTS: One hundred and one patients were >65 years old. The mean ± SD of INR levels, D-dimer levels, and platelet count on the first and the 5th days were 1.22 ± 0.77 and 1.36 ± 1.16; 4.624 ± 3.533 μg/L and 4.334 ± 3.365 μg/L; and 160.162 ± 117.203/μl and 234.070 ± 126.816/μl. There was a significant correlation between age (p = 0.002), INR levels on the 5th day (p = 0.041), platelet count on the 5th day (0.012) with clinical outcomes of patients.
CONCLUSION: There is a significant increase in the average platelets and INR levels on day 5. There is a significant correlation between INR levels and platelet count on 5th days with clinical outcomes of patients.
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Copyright (c) 2022 Dedy Kurnia, Eti Yerizel, Andani Ekaputra, Dwitya Elvira (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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