Cryptosporidium Sp. Findings and Its Symptomatology among Immunocompromised Patients

Authors

  • Dewi Masyithah Darlan Department of Parasitology, Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan Baru, Medan, Sumatera Utara, Indonesia
  • Muhammad Fakhrur Rozi Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan Baru, Medan, Sumatera Utara, Indonesia
  • Yunilda Andriyani Department of Parasitology, Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan Baru, Medan, Sumatera Utara, Indonesia
  • Hemma Yulfi Department of Parasitology, Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan Baru, Medan, Sumatera Utara, Indonesia
  • Restuti Hidayani Saragih Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan, Sumatera Utara, Indonesia
  • Nerdy Nerdy Department of Pharmaceutical Chemistry, Academy of Pharmacy Yayasan Tenaga Pembangunan Arjuna, Pintubosi, Laguboti, Toba Samosir, Sumatera Utara, Indonesia, 22381 http://orcid.org/0000-0002-1993-4415

DOI:

https://doi.org/10.3889/oamjms.2019.329

Keywords:

Cryptosporidium sp., Diarrhea, Protozoa

Abstract

BACKGROUND: Cryptosporidium sp. is an apicomplexan protozoa, and it is related to an immunocompromised state. As it develops diverse clinical manifestations, mild to life-threatening conditions, administration of anti-parasitic medication and its management remain problematic.

AIM: The study aimed to provide Cryptosporidiosis symptomatology and its prevalence among HIV-infected patients in a tertiary referral hospital, Haji Adam Malik General Hospital, Medan, Indonesia.

MATERIAL AND METHODS: Symptomatology was noted using short-questionnaire, and laboratory findings were obtained from the hospital medical record registry on the same day of admission. We enrolled 24 patients were suffered from HIV infection for a certain period and more than one-week diarrhoea including 18 males and 6 females. Routine faeces examination using wet mount, Kinyoun-gabet, and trichrome staining was performed for all samples in Parasitology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia. Numerical data were evaluated using the Mann-Whitney test while Fisher Exact test was used to determine any association between categorical variables.

RESULTS: Our study found that 8 of 24 patients were positive with Cryptosporidium sp. while its symptomatology including abdominal cramp (66.7%), nausea and vomiting (70.8%), and fever (62.5%) is prevalent from our study. We obtained significant association between CD4 cell count (p = 0.006), diarrhea duration (p = 0.007), abdominal pain (p = 0.005), and nausea and vomiting (p = 0.021) with cryptosporidiosis.

CONCLUSION: High consideration of several symptoms related to cryptosporidiosis leads a clinician to initiate prompt management particularly in a high-risk population.

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Author Biography

Nerdy Nerdy, Department of Pharmaceutical Chemistry, Academy of Pharmacy Yayasan Tenaga Pembangunan Arjuna, Pintubosi, Laguboti, Toba Samosir, Sumatera Utara, Indonesia, 22381

Department of Pharmaceutical Chemistry, Academy of Pharmacy Yayasan Tenaga Pembangunan Arjuna, Pintubosi, Laguboti, Toba Samosir, Sumatera Utara, Indonesia, 22381

https://www.scopus.com/authid/detail.uri?authorId=56366211400

http://orcid.org/0000-0002-1993-4415

https://scholar.google.co.id/citations?user=sCn68VYAAAAJ&hl=en

http://sinta2.ristekdikti.go.id/authors/detail?id=6158627&view=overview

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Published

2019-05-14

How to Cite

1.
Darlan DM, Rozi MF, Andriyani Y, Yulfi H, Saragih RH, Nerdy N. Cryptosporidium Sp. Findings and Its Symptomatology among Immunocompromised Patients. Open Access Maced J Med Sci [Internet]. 2019 May 14 [cited 2024 May 26];7(10):1567-71. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.329

Issue

Section

A - Basic Science

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