Hypercoagulable State and Glycemic Control in Diabetic Patients with Malignancy

Abstract

BACKGROUND: Diabetes and malignancy are two chronic diseases that have a major impact on the healthy population in developing countries, both contribute to the increase of morbidity and mortality of the patients. Diabetes presented with hyperglycemia due to insufficiency or resistance of insulin has been associated with an increased risk of thrombosis. Malignancy or cancer is number two killer in the developing countries after infectious diseases, one of the most common cause of death in cancer despite the disease itself is thrombosis, which occurred frequently as cancer cause changes in tumor biology, abnormal vascularisation, endothelial dysfunction, activation of coagulation and inflammation. Poor glucose control reflects by HbA1C has a significant correlation with a hypercoagulable state.

AIM: This study was to evaluate the relation between hypercoagulable state and glycemic control in diabetic patients with malignancy.

METHODS: This is a case control study, eighty  samples diabetes (40 samples were diabetes with malignancy) were collected from private hospitals and clinics. HbA1c, blood glucose level and Ddimer were measured.

RESULTS: The forty five percent of the blood glucose level of the samples was not well controlled.  Sixty five percent of the samples in this group were norm weight, overweight 20% and obese 10%. The Ddimer levels were elevated in both groups and there was a significant correlation between HbA1C and Ddimer (p-0.046), blood glucose and age (p = 0.017).

CONCLUSION: Chronic hyperglycemia will increase the risk of hypercoagulable state, that will also increase the morbidity and mortality rate in diabetes with malignancy patients.